About: The ‘delayed infection’ (aka ‘hygiene’) hypothesis for childhood leukaemia

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About: The ‘delayed infection’ (aka ‘hygiene’) hypothesis for childhood leukaemia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The ‘delayed infection’ (aka ‘hygiene’) hypothesis for childhood leukaemia
Creator	Greaves, Mel
Source	PMC
abstract	The common variant of childhood acute lymphoblastic leukaemia (cALL) is the most frequent paediatric cancer subtype. Its incidence rate appears to have increased substantially in Western societies during the mid-20th century and continues to increase at ∼1%/year. Worldwide cALL appears to track with affluence of societies. The ‘delayed infection’ hypothesis, first formulated in 1988, parallels the hygiene hypothesis and has an evolutionary foundation in the concept of a mismatch between prior genetic selection and programming (of the immune system) and contemporary social circumstances. In essence, the hypothesis predicts that ALL is triggered by an abnormal immune response to one or more common microbial infections and that the abnormality arises for two reasons: (i) infectious exposures being delayed beyond the immunologically anticipated period of infancy; (ii) some degree of inherited genetic susceptibility via, for example, allelic variation in genes involved in the MHC and/or immune response network. The hypothesis also has a framework in the underlying cell and molecular biology of ALL and its natural history. Epidemiological studies of social contacts in infancy (as a proxy for common infections) and risk of ALL provide indirect but strong support for the hypothesis. The idea still requires mechanistic and genetic endorsement and the appropriate studies are in progress.
has issue date	2009-12-17(xsd:dateTime)
bibo:doi	10.1007/978-3-7643-8903-1_13
has license	no-cc
sha1sum (hex)	654dd6f15e55c3bee4ed564fad2f282a75ec468b
schema:url	https://doi.org/10.1007/978-3-7643-8903-1_13
resource representing a document's title	The ‘delayed infection’ (aka ‘hygiene’) hypothesis for childhood leukaemia
has PubMed Central identifier	PMC7123988
schema:publication	The Hygiene Hypothesis and Darwinian Medicine
resource representing a document's body	covid:654dd6f15e55c3bee4ed564fad2f282a75ec468b#body_text
is schema:about of	named entity 'STUDIES' named entity 'INFECTIONS' named entity 'INCIDENCE RATE' named entity 'PROGRAMMING' named entity 'ABNORMAL' named entity 'ANTICIPATED' named entity 'SOCIAL' named entity 'IN PROGRESS' named entity 'NETWORK' named entity 'COMMON' named entity 'social contacts' named entity 'Western' named entity 'epidemiology' named entity 'genetic screening' named entity 'stem cells' named entity 'Ionising radiation' named entity 'SNP' named entity 'communist regime' named entity 'reunification of Germany' named entity 'leukaemia' named entity 'streptococcal' named entity 'immune systems' named entity 'potential windows' named entity 'Down's syndrome' named entity 'copy number variation' named entity 'allergies' named entity 'genotoxic' named entity 'free radicals' named entity 'RUNX1' named entity 'parasites' named entity 'NCoR' named entity 'scarlet fever' named entity 'measles' named entity 'infection' named entity 'pathogenesis' named entity 'HPV' named entity 'mutation' named entity 'enhancer' named entity 'leukaemia virus' named entity 'ETV6' named entity 'Costa Rica' named entity 'leukaemia' named entity 'IGH' named entity 'allergy' named entity 'gene' named entity 'aetiologies' named entity 'clonal selection' named entity 'genetic susceptibility' named entity 'social engineering' named entity 'CNV' named entity 'immune systems' named entity 'infection' named entity 'RUNX1' named entity 'Europe' named entity 'Scandinavia' named entity 'atomic bomb' named entity 'drinking water' named entity 'RAG1/2' named entity 'young adults' named entity 'viruses' named entity 'developed countries' named entity 'autoimmune' named entity 'tenable' named entity 'leukaemia' named entity 'natural selection' named entity 'Central American' named entity 'AML' named entity 'Scandinavia' named entity 'murine' named entity 'infection' named entity 'young adults' named entity 'cell progenitors' named entity 'herd immunity' named entity 'symbiont' named entity 'postnatal' named entity 'allelic' named entity 'vaccine' named entity 'Tab. 1' named entity 'clone' named entity 'hygiene hypothesis' named entity 'United Kingdom' named entity 'genetic variation' named entity 'p27'

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