About: Activation of Interleukin-32 Pro-Inflammatory Pathway in Response to Influenza A Virus Infection

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About: Activation of Interleukin-32 Pro-Inflammatory Pathway in Response to Influenza A Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Activation of Interleukin-32 Pro-Inflammatory Pathway in Response to Influenza A Virus Infection
Creator	Zhu, Ying Li, Wei Wu, Jianguo Liu, Yan Chen, Xin Gong, Rui Peng, Guiqing Kang, Lei Hao, Qian Chen, Yanni Gao, Yecheng Pan, Ying Mahmood Mukhtar, Muhammad Rasool, Sahibzada
source	Medline; PMC
abstract	BACKGROUND: Interleukin (IL)-32 is a recently described pro-inflammatory cytokine that has been reported to be induced by bacteria treatment in culture cells. Little is known about IL-32 production by exogenous pathogens infection in human individuals. METHODS AND FINDINGS: In this study, we found that IL-32 level was increased by 58.2% in the serum samples from a cohort of 108 patients infected by influenza A virus comparing to that of 115 healthy individuals. Another pro-inflammatory factor cyclooxygenase (COX)-2-associated prostaglandin E2 was also upregulated by 2.7-fold. Expression of IL-32 in influenza A virus infected A549 human lung epithelial cells was blocked by either selective COX-2 inhibitor NS398 or Aspirin, a known anti-inflammatory drug, indicating IL-32 was induced through COX-2 in the inflammatory cascade. Interestingly, we found that COX-2-associate PGE(2) production activated by influenza virus infection was significantly suppressed by over-expression of IL-32 but increased by IL-32-specific siRNA, suggesting there was a feedback mechanism between IL-32 and COX-2. CONCLUSIONS: IL-32 is induced by influenza A virus infection via COX-2 in the inflammatory cascade. Our results provide that IL-32 is a potential target for anti-inflammatory medicine screening.
has issue date	2008-04-16(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0001985
bibo:pmid	18414668
has license	cc-by
sha1sum (hex)	6567692317d79659efda807e54ced960c8588ffb
schema:url	https://doi.org/10.1371/journal.pone.0001985
resource representing a document's title	Activation of Interleukin-32 Pro-Inflammatory Pathway in Response to Influenza A Virus Infection
has PubMed Central identifier	PMC2288676
has PubMed identifier	18414668
schema:publication	PLoS One
resource representing a document's body	covid:6567692317d79659efda807e54ced960c8588ffb#body_text
is schema:about of	named entity 'Interleukin' named entity 'TREATMENT' named entity 'BACTERIA ' named entity 'DESCRIBED' named entity 'KNOWN' named entity 'CYTOKINE ' named entity 'CELLS' named entity 'PATHOGENS' named entity 'RECENTLY' named entity 'INDIVIDUALS' named entity 'CULTURE' named entity 'BACKGROUND' named entity 'PRO-INFLAMMATORY CYTOKINE' named entity 'PRO-' named entity 'ACTIVATION' named entity 'REPORTED' named entity 'ABOUT' named entity 'INTERLEUKIN ' named entity 'EXOGENOUS' named entity 'INDUCED' named entity 'PATHWAY' named entity 'LITTLE' named entity 'RESPONSE TO' named entity 'INFLUENZA A VIRUS INFECTION' named entity 'INFLAMMATORY' named entity 'IS A' named entity 'INFECTION' named entity 'INTERLEUKIN-32' named entity 'HUMAN' named entity 'IL-32 PRODUCTION' covid:arg/6567692317d79659efda807e54ced960c8588ffb named entity 'bacteria' named entity 'production' named entity 'culture' named entity 'infection' named entity 'Influenza A Virus' named entity 'agarose gel' named entity 'pro-inflammatory' named entity 'A549' named entity 'human lung' named entity 'mRNA' named entity 'IL-32' named entity 'IL-32' named entity 'Cayman Chemical' named entity 'dsRNA' named entity 'supernatants' named entity 'influenza A virus' named entity 'incubation' named entity 'Enzyme Immunoassay' named entity 'IL-32' named entity 'luciferase' named entity 'infection' named entity 'influenza virus' named entity 'COX-1' named entity 'over-expression' named entity 'lysis buffer' named entity 'IL-32' named entity 'COX' named entity 'cloned' named entity 'IL-32' named entity 'expression levels' named entity 'COX-2' named entity 'A549' named entity 'IL-32' named entity 'macrophages' named entity 'epithelial cells' named entity 'Luciferase' named entity 'COX-2'

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