About: B cell clonal expansion and convergent antibody responses to SARS-CoV-2

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	B cell clonal expansion and convergent antibody responses to SARS-CoV-2
Creator	Yang, Fan Rogers, Angela Lee, Ji-Yeun Kim, Peter Pinsky, Benjamin Roeltgen, Katharina Blish, Catherine Article, Research Boyd, Scott Hoh, Ramona Jackson, Katherine Nielsen, Sandra Powell, Abigail Rustagi, Arjun Wang, Taia
source	Medline; PMC
abstract	During virus infection B cells are critical for the production of antibodies and protective immunity. Establishment of a diverse antibody repertoire occurs by rearrangement of germline DNA at the immunoglobulin heavy and light chain loci to encode the membrane-bound form of antibodies, the B cell antigen receptor. Little is known about the B cells and antigen receptors stimulated by the novel human coronavirus SARS-CoV-2. Here we show that the human B cell compartment in patients with diagnostically confirmed SARS-CoV-2 and clinical COVID-19 is rapidly altered with the early recruitment of B cells expressing a limited subset of V genes, and extensive activation of IgG and IgA subclasses without significant somatic mutation. We detect expansion of B cell clones as well as convergent antibodies with highly similar sequences across SARS-CoV-2 patients, highlighting stereotyped naïve responses to this virus. A shared convergent B cell clonotype in SARS-CoV-2 infected patients was previously seen in patients with SARS. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and other zoonotic spillover coronaviruses.
has issue date	2020-05-06(xsd:dateTime)
bibo:doi	10.21203/rs.3.rs-27220/v1
bibo:pmid	32702737
has license	cc-by
sha1sum (hex)	658608215fcb44553b086a2ece196daacb65af5f
schema:url	https://doi.org/10.21203/rs.3.rs-27220/v1
resource representing a document's title	B cell clonal expansion and convergent antibody responses to SARS-CoV-2
has PubMed Central identifier	PMC7336706
has PubMed identifier	32702737
schema:publication	Res Sq
resource representing a document's body	covid:658608215fcb44553b086a2ece196daacb65af5f#body_text
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