About: On the Regularities of the Polar Profiles of Proteins Related to Ebola Virus Infection and their Functional Domains

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	On the Regularities of the Polar Profiles of Proteins Related to Ebola Virus Infection and their Functional Domains
Creator	Uversky, Vladimir Buhse, Thomas Fernando, • Polanco, Carlos Lino, José Abelardo, • Angola, Marcela Cedano, Bañuelos Chao, Bañuelos Daniel, • Falconi, • Mendoza, Samaniego Paola, Ingrid Ponce De León, Vela Tavera, Michel
Source	Medline; PMC
abstract	The number of fatalities and economic losses caused by the Ebola virus infection across the planet culminated in the havoc that occurred between August and November 2014. However, little is known about the molecular protein profile of this devastating virus. This work represents a thorough bioinformatics analysis of the regularities of charge distribution (polar profiles) in two groups of proteins and their functional domains associated with Ebola virus disease: Ebola virus proteins and Human proteins interacting with Ebola virus. Our analysis reveals that a fragment exists in each of these proteins—one named the “functional domain”—with the polar profile similar to the polar profile of the protein that contains it. Each protein is formed by a group of short sub-sequences, where each fragment has a different and distinctive polar profile and where the polar profile between adjacent short sub-sequences changes orderly and gradually to coincide with the polar profile of the whole protein. When using the charge distribution as a metric, it was observed that it effectively discriminates the proteins from their functional domains. As a counterexample, the same test was applied to a set of synthetic proteins built for that purpose, revealing that any of the regularities reported here for the Ebola virus proteins and human proteins interacting with Ebola virus were not present in the synthetic proteins. Our results indicate that the polar profile of each protein studied and its corresponding functional domain are similar. Thus, when building each protein from its functional domai—adding one amino acid at a time and plotting each time its polar profile—it was observed that the resulting graphs can be divided into groups with similar polar profiles.
has issue date	2018-03-06(xsd:dateTime)
bibo:doi	10.1007/s12013-018-0839-4
bibo:pmid	29511990
has license	no-cc
sha1sum (hex)	658ec24d2cd06a1b2bcbf4bf1d9c564065b1d10f
schema:url	https://doi.org/10.1007/s12013-018-0839-4
resource representing a document's title	On the Regularities of the Polar Profiles of Proteins Related to Ebola Virus Infection and their Functional Domains
has PubMed Central identifier	PMC7090660
has PubMed identifier	29511990
schema:publication	Cell Biochem Biophys
resource representing a document's body	covid:658ec24d2cd06a1b2bcbf4bf1d9c564065b1d10f#body_text
is schema:about of	named entity 'losses' named entity 'graphs' named entity 'number' named entity 'November' named entity 'short' named entity 'functional' named entity 'KNOWN' named entity 'EBOLA VIRUS DISEASE' named entity 'METRIC' named entity 'ASSOCIATED WITH' named entity 'VIRUS' named entity 'CHANGES' named entity 'RESULTS' named entity 'PROTEIN ' named entity 'SHORT' named entity 'OCCURRED' named entity 'USING' named entity 'OBSERVED' named entity 'APPLIED' named entity 'GRAPHS' named entity 'DIFFERENT' named entity 'SUB-' named entity 'SYNTHETIC' named entity 'CAUSED BY' named entity 'FORMED' named entity 'WORK' named entity 'ABOUT' named entity 'NOT PRESENT' named entity 'MOLECULAR' named entity 'ECONOMIC' named entity 'THESE' named entity 'PLANET' named entity 'CHARGE DISTRIBUTION' named entity 'ADJACENT' named entity 'ADDING' named entity 'OUR' named entity 'LITTLE' named entity 'REPORTED' named entity 'FUNCTIONAL' named entity 'PURPOSE' named entity 'PROFILE' named entity 'NOVEMBER' named entity 'EBOLA VIRUS' named entity 'TIME' named entity 'EBOLA VIRUS INFECTION' named entity 'REVEALS' named entity 'HUMAN PROTEINS' named entity 'WHERE' named entity 'TEST' named entity 'NAMED' named entity 'HERE' named entity 'BIOINFORMATICS ANALYSIS' named entity 'FATALITIES' named entity 'PROTEIN' named entity 'ACROSS' named entity 'THEIR' named entity 'PROTEIN PROFILE' named entity 'INTERACTING' named entity 'OF EACH' named entity 'ANALYSIS' named entity 'THEIR' named entity 'RELATED' named entity 'FUNCTIONAL' named entity 'POLAR' named entity 'BUILDING' named entity 'RESULTING' named entity 'ITS'

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