About: Clinical impact of rapid molecular detection of respiratory pathogens in patients with acute respiratory infection

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About: Clinical impact of rapid molecular detection of respiratory pathogens in patients with acute respiratory infection Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical impact of rapid molecular detection of respiratory pathogens in patients with acute respiratory infection
Creator	Carballal, G Echavarría, M Ekstrom, J Marcone, D O'farrell, C Querci, M Seoane, A Vidaurreta, S Videla, C Ypas, M
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Acute respiratory infections (ARI) are a leading cause of morbidity and mortality worldwide. There is a need to demonstrate the clinical impact of using the new, rapid and sensitive molecular assays in prospectively designed studies. OBJECTIVES: To study the impact on medical management of a rapid molecular assay in patients with respiratory infections. STUDY DESIGN: A prospective, randomized, non-blinded study was performed in patients presenting to the Emergency Department during two respiratory seasons (2016–2017). Diagnosis was performed by FilmArray Respiratory Panel (FilmArray-RP) or by immunofluorescence assay (IFA). RESULTS: A total of 432 patients (156 children and 276 adults) were analyzed. Diagnosis with FilmArray-RP was associated with significant changes in medical management including withholding antibiotic prescriptions (OR:15.52, 95%CI:1.99–120.83 in adults and OR:12.23, 95%CI:1.56–96.09 in children), and reduction in complementary studies in children (OR:9.64, 95%CI:2.13–43.63) compared to IFA. Decrease in oseltamivir prescriptions was significantly higher in adults in the FilmArray-RP group (p = 0.042; OR:1.19, 95%CI:0.51-2.79) compared to adults managed with IFA. Diagnostic yield was significantly higher by FilmArray-RP (81%) than by IFA (31%)(p < 0.001). The median time from sample collection to reporting was 1 h 52 min by FilmArray-RP and 26 h by IFA (p < 0.001). CONCLUSIONS: The high respiratory viruses’ detection rate and availability of results within two hours when using FilmArray-RP were associated with decreases in antibiotic prescriptions and complementary studies and more accurate use of oseltamivir.
has issue date	2018-09-14(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2018.09.009
bibo:pmid	30267999
has license	no-cc
sha1sum (hex)	6590855e7d8b1204c516d46ce501f9fe86345057
schema:url	https://doi.org/10.1016/j.jcv.2018.09.009
resource representing a document's title	Clinical impact of rapid molecular detection of respiratory pathogens in patients with acute respiratory infection
has PubMed Central identifier	PMC7172208
has PubMed identifier	30267999
schema:publication	J Clin Virol
resource representing a document's body	covid:6590855e7d8b1204c516d46ce501f9fe86345057#body_text
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