About: Evaluation of remodeling and regeneration of electrospun PCL/fibrin vascular grafts in vivo

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About: Evaluation of remodeling and regeneration of electrospun PCL/fibrin vascular grafts in vivo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of remodeling and regeneration of electrospun PCL/fibrin vascular grafts in vivo
Creator	Yang, Lei Zhang, Rui Zhao, Liang Chen, Hongli Li, Qiong Li, Xiafei Dong, Yuzhen Mu, Songfeng Song, Shuang Sun, Lulu Wang, Fengyao Wang, Shicheng Yang, Chengqiang Zhang, Qiqing Zhao, Changhong Zong, Haibin
Source	Elsevier; PMC
abstract	Abstract The success of artificial vascular graft in the host to obtain functional tissue regeneration and remodeling is a great challenge in the field of small diameter tissue engineering blood vessels. In our previous work, poly(ε-caprolactone) (PCL)/fibrin vascular grafts were fabricated by electrospinning. It was proved that the PCL/fibrin vascular graft was a suitable small diameter tissue engineering vascular scaffold with good biomechanical properties and cell compatibility. Here we mainly examined the performance of PCL/fibrin vascular graft in vivo. The graft showed randomly arranged nanofiber structure, excellent mechanical strength, higher compliance and degradation properties. At 9 months after implantation in the rat abdominal aorta, the graft induced the regeneration of neoarteries, and promoted ECM deposition and rapid endothelialization. More importantly, the PCL/fibrin vascular graft showed more microvessels density and fewer calcification areas at 3 months, which was beneficial to improve cell infiltration and proliferation. Moreover, the ratio of M2/M1macrophage in PCL/fibrin graft had a higher expression level and the secretion amount of pro-inflammatory cytokines started to increase, and then decreased to similar to the native artery. Thus, the electrospun PCL/fibrin tubular vascular graft had great potential to become a new type of artificial blood vessel scaffold that can be implanted in vivo for long term.
has issue date	2020-08-25(xsd:dateTime)
bibo:doi	10.1016/j.msec.2020.111441
has license	els-covid
sha1sum (hex)	65ae45cbe67a955be968da7fdd96b8bdd81b2950
schema:url	https://doi.org/10.1016/j.msec.2020.111441
resource representing a document's title	Evaluation of remodeling and regeneration of electrospun PCL/fibrin vascular grafts in vivo
has PubMed Central identifier	PMC7445127
schema:publication	Mater Sci Eng C Mater Biol Appl
resource representing a document's body	covid:65ae45cbe67a955be968da7fdd96b8bdd81b2950#body_text
is schema:about of	named entity 'secretion' named entity 'phenotype' named entity 'secretion' named entity '1:200' named entity 'aspirin' named entity 'biocompatibility' named entity 'elastin' named entity 'fibrin' named entity 'fibrin' named entity 'endothelial cell' named entity 'Shanghai' named entity 'CD34' named entity 'standard deviation' named entity 'macrophages' named entity 'nanofibers' named entity 'fibrin' named entity 'tissue regeneration' named entity 'vWF' named entity 'blood vessel' named entity 'fibrin' named entity 'fibrin' named entity 'abdominal aorta' named entity 'iodophor' named entity 'fibrin' named entity 'vascular grafts' named entity 'CD68' named entity 'TNF-α' named entity 'fibrin' named entity 'lumen' named entity 'fibrin' named entity 'Mpa' named entity 'CD68' named entity 'fibrin' named entity 'vascular graft' named entity 'native arteries' named entity 'solvent' named entity 'morphology' named entity 'CD31' named entity 'anti-inflammatory' named entity 'collagen' named entity 'lumen' named entity 'Immunofluorescence' named entity 'adhesion' named entity 'tissue regeneration' named entity 'Sigma Aldrich' named entity 'stereo microscope' named entity 'cytokines' named entity 'vasoconstriction' named entity 'fibrin' named entity 'fibrin' named entity 'fluorescence microscope' named entity 'statistical significance' named entity 'fibrin' named entity 'microvessels' named entity 'KCl' named entity 'blood vessel' named entity 'fibrin' named entity 'fibrin' named entity 'fibrin' named entity 'fibrin' named entity 'raw material' named entity 'pro-inflammatory cytokines' named entity 'macrophages' named entity 'antibody' named entity 'secretion' named entity 'fibrin' named entity 'secondary antibody' named entity 'pore structure'

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