About: Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort
Creator	Rello, Jordi Chiche, Jean-Daniel Hinds, Charles Gordon, Anthony Stueber, Frank Clarke, Geraldine Garrard, Christopher Hutton, Paula Mckechnie, Stuart Walden, Andrew
source	PMC
abstract	INTRODUCTION: Community acquired pneumonia (CAP) is the most common infectious reason for admission to the Intensive Care Unit (ICU). The GenOSept study was designed to determine genetic influences on sepsis outcome. Phenotypic data was recorded using a robust clinical database allowing a contemporary analysis of the clinical characteristics, microbiology, outcomes and independent risk factors in patients with severe CAP admitted to ICUs across Europe. METHODS: Kaplan-Meier analysis was used to determine mortality rates. A Cox Proportional Hazards (PH) model was used to identify variables independently associated with 28-day and six-month mortality. RESULTS: Data from 1166 patients admitted to 102 centres across 17 countries was extracted. Median age was 64 years, 62% were male. Mortality rate at 28 days was 17%, rising to 27% at six months. Streptococcus pneumoniae was the commonest organism isolated (28% of cases) with no organism identified in 36%. Independent risk factors associated with an increased risk of death at six months included APACHE II score (hazard ratio, HR, 1.03; confidence interval, CI, 1.01-1.05), bilateral pulmonary infiltrates (HR1.44; CI 1.11-1.87) and ventilator support (HR 3.04; CI 1.64-5.62). Haematocrit, pH and urine volume on day one were all associated with a worse outcome. CONCLUSIONS: The mortality rate in patients with severe CAP admitted to European ICUs was 27% at six months. Streptococcus pneumoniae was the commonest organism isolated. In many cases the infecting organism was not identified. Ventilator support, the presence of diffuse pulmonary infiltrates, lower haematocrit, urine volume and pH on admission were independent predictors of a worse outcome.
has issue date	2014-04-01(xsd:dateTime)
bibo:doi	10.1186/cc13812
bibo:pmid	24690444
has license	cc-by
sha1sum (hex)	666b7a42e5eace656f7b8b9a95c8c72a222fce0b
schema:url	https://doi.org/10.1186/cc13812
resource representing a document's title	Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort
has PubMed Central identifier	PMC4056764
has PubMed identifier	24690444
schema:publication	Crit Care
resource representing a document's body	covid:666b7a42e5eace656f7b8b9a95c8c72a222fce0b#body_text
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