About: The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile

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About: The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
Creator	Bohn, Larissa Ganesan, Priya O'donnell, Lauren Chandwani, Manisha Creisher, Patrick
source	Elsevier; Medline; PMC
abstract	Abstract Neonates are highly susceptible to viral infections in the periphery, potentially due to deviant cytokine responses. Here, we investigated the role of interferon-gamma (IFNγ), a key anti-viral in the neonatal brain. We found that (i) IFNγ, which is critical for viral control and survival in adults, delays mortality in neonates, (ii) IFNγ limits infiltration of macrophages, neutrophils, and T cells in the neonatal brain, (iii) neonates and adults differentially express pathogen recognition receptors and Type I interferons in response to the infection, (iv) both neonates and adults express IFNγ and other Th1-related factors, but expression of many cytokines/chemokines and IFNγ-responsive genes is age-dependent, and (v) administration of IFNγ extends survival and reduces CD4 T cell infiltration in the neonatal brain. Our findings suggest age-dependent expression of cytokine/chemokine profiles in the brain and distinct dynamic interplays between lymphocyte populations and cytokines/chemokines in MV-infected neonates.
has issue date	2018-03-15(xsd:dateTime)
bibo:doi	10.1016/j.jneuroim.2017.12.018
bibo:pmid	29366594
has license	els-covid
sha1sum (hex)	666d40a4dbf23fa139910e68c97be3149b50b107
schema:url	https://doi.org/10.1016/j.jneuroim.2017.12.018
resource representing a document's title	The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
has PubMed Central identifier	PMC6003673
has PubMed identifier	29366594
schema:publication	Journal of Neuroimmunology
resource representing a document's body	covid:666d40a4dbf23fa139910e68c97be3149b50b107#body_text
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