About: Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.

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About: Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp. Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.
Creator	Almeida, Celso Kehraus, Stefan König, Gabriele Prudêncio, Miguel
source	Medline; PMC
abstract	The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia sp. cf. C. flammea. Culture on a biomalt medium supplemented with sea salt led to the isolation of three new phthalide derivatives, i.e., marilones A–C (1–3), and the known compound silvaticol (4). The skeleton of marilones A and B is most unusual, and its biosynthesis is suggested to require unique biochemical reactions considering fungal secondary metabolism. Marilone A (1) was found to have antiplasmodial activity against Plasmodium berghei liver stages with an IC(50) of 12.1 µM. Marilone B (2) showed selective antagonistic activity towards the serotonin receptor 5-HT(2B) with a K (i) value of 7.7 µM.
has issue date	2011-12-05(xsd:dateTime)
bibo:doi	10.3762/bjoc.7.192
bibo:pmid	22238541
has license	cc-by
sha1sum (hex)	667001630cb051990f577e069785590fce4b4d14
schema:url	https://doi.org/10.3762/bjoc.7.192
resource representing a document's title	Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.
has PubMed Central identifier	PMC3252867
has PubMed identifier	22238541
schema:publication	Beilstein J Org Chem
resource representing a document's body	covid:667001630cb051990f577e069785590fce4b4d14#body_text
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