About: Effect of antibiotic treatment in preweaned Holstein calves after experimental bacterial challenge with Pasteurella multocida

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About: Effect of antibiotic treatment in preweaned Holstein calves after experimental bacterial challenge with Pasteurella multocida Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effect of antibiotic treatment in preweaned Holstein calves after experimental bacterial challenge with Pasteurella multocida
Creator	Al, Holschbach,
Source	Elsevier; Medline; PMC
abstract	ABSTRACT The primary objective of this randomized controlled challenge study was to investigate the effect of ampicillin on ultrasonographic (US) lung consolidation after experimental challenge with Pasteurella multocida in preweaned dairy calves. The secondary objectives were to determine whether ampicillin affected respiratory score, gross consolidation, or the detection of P. multocida in lung tissue at postmortem exam (PME). Holstein bull calves (n = 39) were transported to the University of Wisconsin-Madison School of Veterinary Medicine isolation facility at the mean (±SD) age of 52 ± 6 d. After a 7-d acclimation period, 30 calves were inoculated intratracheally with 1010 cfu of ampicillin-sensitive P. multocida. Lung US and respiratory scoring were performed 2, 6, 12, and 24 h post-challenge, then US once daily and respiratory scoring twice daily until d 14. Calves were randomized to receive ampicillin [n = 17, treatment (TX), 6.6 mg/kg i.m. once daily for 3 d] or placebo [n = 11, control (CON), saline, equal volume, i.m. once daily for 3 d] when ≥1 cm2 of lung consolidation was observed and ≥6 h had elapsed since challenge. Lung lesions ≥1 cm2 were considered positive for consolidation. Calves were respiratory score positive if ≥2 in 2 or more categories based on the Wisconsin respiratory health score chart. Area under the curve (AUC) was calculated for US score and respiratory score as a proxy for time with consolidation and clinical respiratory disease, respectively. Gross lung lesions and pathogens were quantified following PME. At the time of first treatment, consolidation had developed in 28/30 calves (TX, n = 17; CON, n = 11) and 6% (1 out of 17) of TX and 9% (1 out of 11) of CON calves had a positive respiratory score. The TX calves had a significantly lower median (interquartile range given in parentheses) AUC for US score [TX: 23 (20, 29), CON: 47 (33, 53)], whereas mean AUC for respiratory score was not different between groups (TX: 93 ± 28, CON: 96 ± 17). On d 14, 70% (12 out of 17) of TX and 100% (11 out of 11) of CON calves had lung consolidation, and 24% (4 out of 17) of TX and 27% (3 out of 11) of CON calves had clinical respiratory disease. On PME, median consolidation was 10% (6, 15) for TX and 10% (2, 28) for CON calves. Lung cultures were positive for P. multocida in 77% (13 out of 17) of TX and 91% (10 out of 11) of CON calves. Lung health benefited from a 3-d ampicillin therapy, but benefits were short-lived. Treatment failures might be due to incomplete resolution of the initial lung infection. Future studies are needed to optimize TX strategies to improve long-term lung health.
has issue date	2019-12-31(xsd:dateTime)
bibo:doi	10.3168/jds.2019-16992
bibo:pmid	31548072
has license	els-covid
sha1sum (hex)	66a2dd6ca8b561cce530ee63e8b99890270ecba1
schema:url	https://doi.org/10.3168/jds.2019-16992
resource representing a document's title	Effect of antibiotic treatment in preweaned Holstein calves after experimental bacterial challenge with Pasteurella multocida
has PubMed Central identifier	PMC7094633
has PubMed identifier	31548072
schema:publication	Journal of Dairy Science
resource representing a document's body	covid:66a2dd6ca8b561cce530ee63e8b99890270ecba1#body_text
is schema:about of	named entity 'CON' named entity 'calves' named entity 'consolidation' named entity 'placebo' named entity 'facility' named entity 'P. multocida' named entity 'Veterinary Medicine' named entity 'score' named entity 'consolidation' named entity 'score' named entity 'respiratory' named entity 'calves' named entity 'lesions' named entity 'daily' named entity 'RANGE' named entity 'MEAN' named entity 'DETERMINE' named entity 'OBJECTIVES' named entity 'POSITIVE FOR' named entity 'MADISON' named entity 'GROUPS' named entity 'DAIRY CALVES' named entity 'SCHOOL' named entity 'BASED' named entity 'FAILURES' named entity 'RECEIVE' named entity 'DUE TO' named entity 'NEEDED' named entity 'CALVES' named entity 'ISOLATION' named entity 'SCORING' named entity 'RANDOMIZED' named entity 'SALINE' named entity 'STRATEGIES' named entity 'LONG-TERM' named entity 'AUC' named entity 'PME' named entity 'CHART' named entity 'EXAM' named entity 'HEALTH' named entity 'LESIONS' named entity 'DETECTION' named entity 'INCOMPLETE' named entity '283' named entity 'AGE' named entity 'LUNG TISSUE' named entity 'LUNG CONSOLIDATION' named entity 'TWICE DAILY' named entity 'RESOLUTION' named entity 'PATHOGENS' named entity 'POSTMORTEM' named entity 'AMPICILLIN' named entity 'RESPIRATORY' named entity 'VETERINARY MEDICINE' named entity 'TIME' named entity 'VOLUME' named entity 'MIGHT BE' named entity 'ONCE DAILY' named entity 'OBSERVED' named entity 'PASTEURELLA MULTOCIDA ' named entity 'PERIOD' named entity 'MG%' named entity 'POSITIVE' named entity '70%' named entity 'OPTIMIZE' named entity 'POST' named entity 'BENEFITS' named entity 'FIRST TREATMENT' named entity 'EQUAL' named entity 'PLACEBO' named entity 'SECONDARY' named entity 'A 7' named entity 'CONTROLLED' named entity 'D 14' named entity 'CFU' named entity 'ACCLIMATION' named entity 'A56' covid:arg/66a2dd6ca8b561cce530ee63e8b99890270ecba1 named entity 'CALVES' named entity 'UNIVERSITY'

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