About: Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort; MaastrICCht

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About: Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort; MaastrICCht Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort; MaastrICCht
Creator	Wildberger, Joachim Oude Lashof, Astrid Acampo-De Jong, Melanie Aries, Marcel Bekers, Otto Bels, Julia Bennis, Frank Bergmans, Dennis Buhre, Wolfgang Coen, D Delnoy, Thijs Donkers, Moniek Driessen, Rob Geyik, Zafer Ghossein-Doha, Chahinda Groven, Rald Heijnen, Nanon Heines, Serge Hermans, Ben Janssen, Marcus Koelmann, Marcel Kubben, Pieter Maastriccht, Cohort Meex, Steven Mingels, Alma Mulder, Mark Nicolaes, Gerry Savelkoul, Paul Schnabel, Ronny Sels, Jan-Willem Stehouwer, Strauch, Uli Tas, Jeanette Tijssen, Fabian Van Bussel, Bas Van De Poll, Marcel Van Der Horst, Iwan Van Gassel, Rob Van Kuijk, Sander Van Mook, Walther Van Rosmalen, Frank Van Santen, Susanne Verbunt, Jeanine Walraven, Kim
source	MedRxiv
abstract	Background: The course of the disease in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in mechanically ventilated patients is unknown. To unravel the clinical heterogeneity of the SARS-CoV-2 infection in these patients, we designed the prospective observational Maastricht Intensive Care COVID cohort; MaastrICCht. We incorporated serial measurements that harbour aetiological, diagnostic and predictive information. The study aims to investigate the heterogeneity of the natural course of critically ill patients with SARS-CoV-2 infection. Study population: Mechanically ventilated patients admitted to the Intensive Care with SARS-CoV-2 infection. Main message: We will collect clinical variables, vital parameters, laboratory variables, mechanical ventilator settings, chest electrical impedance tomography, electrocardiograms, echocardiography as well as other imaging modalities to assess heterogeneity of the natural course of SARS-CoV-2 infection in critically ill patients. The MaastrICCht cohort is, also designed to foster various other studies and registries and intends to create an open-source database for investigators. Therefore, a major part of the data collection is aligned with an existing national Intensive Care data registry and two international COVID-19 data collection initiatives. Additionally, we create a flexible design, so that additional measures can be added during the ongoing study based on new knowledge obtained from the rapidly growing body of evidence. Conclusion: The spread of the COVID-19 pandemic requires the swift implementation of observational research to unravel heterogeneity of the natural course of the disease of SARS-CoV-2 infection in mechanically ventilated patients. Our design is expected to enhance aetiological, diagnostic and prognostic understanding of the disease. This paper describes the design of the MaastrICCht cohort.
has issue date	2020-05-01(xsd:dateTime)
bibo:doi	10.1101/2020.04.27.20080309
has license	medrxiv
sha1sum (hex)	66f5297a476dcd4232083ac567a3b9588a03742e
schema:url	https://doi.org/10.1101/2020.04.27.20080309
resource representing a document's title	Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort; MaastrICCht
resource representing a document's body	covid:66f5297a476dcd4232083ac567a3b9588a03742e#body_text
is schema:about of	named entity 'patients' named entity 'Maastricht' named entity 'heterogeneity' named entity 'Intensive Care' named entity 'aims' named entity 'infection' named entity 'measurements' named entity 'severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)' named entity 'COVID' named entity 'infection' named entity 'aetiological' named entity 'Intensive Care' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'Intensive Care' named entity 'COVID-19' named entity 'neuromuscular blockade' named entity 'overfitting' named entity 'SARS-CoV-2' named entity 'institutional review board' named entity 'mechanical ventilation' named entity 'medical research' named entity 'preprint' named entity 'Akaike Information Criterion' named entity 'Maastricht UMC+' named entity 'cardiovascular disease' named entity 'Germany' named entity 'peer review' named entity 'Intensive Care' named entity 'observational studies' named entity 'mechanical ventilation' named entity 'thrombotic events' named entity 'preprint' named entity 'negative likelihood ratio' named entity 'COVID-19' named entity 'medRxiv' named entity 'preprint' named entity 'data sharing' named entity 'electrocardiography' named entity 'CT-scans' named entity 'preprint' named entity 'COVID-19 pandemic' named entity 'case report form'

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