About: SARS-coronavirus replicates in mononuclear cells of peripheral blood (PBMCs) from SARS patients

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About: SARS-coronavirus replicates in mononuclear cells of peripheral blood (PBMCs) from SARS patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-coronavirus replicates in mononuclear cells of peripheral blood (PBMCs) from SARS patients
Creator	Wu, Nanping Li, Lanjuan Hu, Minjun Li, Minwei Shao, Junbing Wo, Jianer Yao, Hangpin Zhu, Haihong Dennin, Reinhard
Source	Elsevier; Medline; PMC
abstract	Background: The etiologic agent of severe acute respiratory syndrome (SARS) is a recently identified, positive single-stranded RNA (ssRNA) coronavirus (SARS-CoV). Little is known about the dynamic changes of the viral replicative form in SARS cases. Objectives: Evaluate whether SARS-CoV can infect and replicate in peripheral blood mononuclear cells (PBMCs) of infected persons and reveal any dynamic changes to the virus during the course of the disease. Study design: Peripheral blood mononuclear cells collected from SARS cases infected by the same infectious source were tested for both negative-stranded RNA (minus-RNA, “replicative intermediates”) and positive-stranded RNA (genomic RNA) of SARS-CoV during the course of hospitalization by reverse transcription-polymerase chain reaction (RT-PCR). Results: SARS-CoV minus-RNA was detected in PBMCs from SARS patients. The viral replicative forms in PBMCs were detectable during a period of 6 days post-onset of the disease, while the plus-RNA were detectable for a longer period (8–12 days post-onset). Conclusions: SARS-coronavirus can infect and replicate within PBMCs of SARS patients, but viral replication in PBMCs seems subject to self-limitation.
has issue date	2003-08-30(xsd:dateTime)
bibo:doi	10.1016/s1386-6532(03)00195-1
bibo:pmid	14522061
has license	no-cc
sha1sum (hex)	6769898a0dfadfae27529a1e5a82ac1c523c968d
schema:url	https://doi.org/10.1016/s1386-6532%2803%2900195-1
resource representing a document's title	SARS-coronavirus replicates in mononuclear cells of peripheral blood (PBMCs) from SARS patients
has PubMed Central identifier	PMC7128964
has PubMed identifier	14522061
schema:publication	J Clin Virol
resource representing a document's body	covid:6769898a0dfadfae27529a1e5a82ac1c523c968d#body_text
is schema:about of	named entity 'PERIPHERAL BLOOD' named entity 'CHANGES' named entity 'INFECTIOUS' named entity 'PBMCS' named entity 'MINUS' named entity 'EVALUATE' named entity 'DYNAMIC' named entity 'VIRUS' named entity 'PATIENTS' named entity 'detectable' named entity 'viral' named entity 'virus' named entity 'severe acute respiratory syndrome (SARS)' named entity 'SARS-CoV' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'LIMITATION' named entity 'TESTED FOR' named entity 'POST' named entity 'REPLICATE' named entity 'BUT' named entity 'PERIOD' named entity 'VIRAL REPLICATION' named entity 'ONSET' named entity 'KNOWN' named entity 'ONSET OF' named entity 'BACKGROUND' named entity 'POLYMERASE CHAIN REACTION' named entity 'ETIOLOGIC AGENT' named entity 'INFECTED' named entity 'STUDY DESIGN' named entity '288' named entity 'SARS' named entity 'REPLICATES' named entity 'PCR' named entity 'CORONAVIRUS' named entity 'NEGATIVE' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'FORM' named entity 'REVEAL' named entity 'DAYS' named entity 'INFECT' named entity 'SOURCE' named entity 'VIRAL' named entity 'OBJECTIVES' named entity 'INTERMEDIATES' named entity 'LITTLE' named entity 'DETECTABLE' named entity 'POSITIVE' named entity 'IS A' named entity 'PATIENTS' named entity 'MONONUCLEAR CELLS' named entity 'CORONAVIRUS' named entity 'RNA' named entity 'CASES' named entity 'SELF' named entity 'RECENTLY' named entity 'REVERSE TRANSCRIPTION' named entity 'DETECTED' named entity 'DISEASE' named entity 'RESULTS' named entity 'COURSE' named entity 'SARS' named entity 'CONCLUSIONS' named entity 'HOSPITALIZATION' named entity 'COLLECTED' named entity 'FORMS' named entity 'IDENTIFIED' named entity 'PERSONS' named entity 'ABOUT' named entity 'SUBJECT' named entity 'SARS-COV' covid:arg/6769898a0dfadfae27529a1e5a82ac1c523c968d named entity 'SARS-CoV'

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