About: miRNomes of haematopoietic stem cells and dendritic cells identify miR-30b as a regulator of Notch1

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About: miRNomes of haematopoietic stem cells and dendritic cells identify miR-30b as a regulator of Notch1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	miRNomes of haematopoietic stem cells and dendritic cells identify miR-30b as a regulator of Notch1
Creator	Cao, Xuetao Zhang, Qian Chen, Yongjian Gu, Yan Han, Yanmei Hou, Jin Jiang, Minghong Qian, Cheng Su, Xiaoping
topic	covid:67a52569919632f4bf58782538ff24838ac7f26c#this
Source	PMC
abstract	Dendritic cells (DCs) are critical to initiate the immune response and maintain tolerance, depending on different status and subsets. The expression profiles of microRNAs (miRNAs) in various DC subsets and haematopoietic stem cells (HSCs), which generate DCs, remain to be fully identified. Here we examine miRNomes of mouse bone marrow HSCs, immature DCs, mature DCs and IL-10/NO-producing regulatory DCs by deep sequencing. We identify numerous stage-specific miRNAs and histone modification in HSCs and DCs at different differentiation stages. miR-30b, significantly upregulated via a TGF-beta/Smad3-mediated epigenetic pathway in regulatory DCs, can target Notch1 to promote IL-10 and NO production, suggesting that miR-30b is a negative regulator of immune response. We also identify miRNomes of in vivo counterparts of mature DCs and regulatory DCs and systematically compare them with DCs cultured in vitro. These results provide a resource for studying roles of miRNAs in stem cell biology, development and functional regulation of DC subsets.
has issue date	2013-12-06(xsd:dateTime)
bibo:doi	10.1038/ncomms3903
bibo:pmid	24309499
has license	cc-by-nc-sa
sha1sum (hex)	67a52569919632f4bf58782538ff24838ac7f26c
schema:url	https://doi.org/10.1038/ncomms3903
resource representing a document's title	miRNomes of haematopoietic stem cells and dendritic cells identify miR-30b as a regulator of Notch1
has PubMed Central identifier	PMC3863901
has PubMed identifier	24309499
schema:publication	Nat Commun
resource representing a document's body	covid:67a52569919632f4bf58782538ff24838ac7f26c#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/67a52569919632f4bf58782538ff24838ac7f26c
is schema:about of	named entity 'ARTICLE' named entity 'DEEP SEQUENCING' named entity 'PATHWAY' named entity 'NO PRODUCTION' named entity 'IMMUNE RESPONSE' named entity 'STAGES' named entity 'THESE' named entity 'COMPARE' named entity 'HAEMATOPOIETIC' named entity 'VARIOUS' named entity 'STATUS' named entity 'DENDRITIC CELLS' named entity 'TOLERANCE' named entity 'IDENTIFY' named entity 'CULTURED' named entity 'MIR' named entity 'HAEMATOPOIETIC' covid:arg/67a52569919632f4bf58782538ff24838ac7f26c named entity 'MEDIATED' named entity 'STEM CELLS' named entity 'HERE' named entity '10%' named entity 'IN VITRO' named entity 'IS A' named entity 'STEM CELLS' named entity 'IDENTIFY' named entity 'REGULATOR' named entity 'NOTCH1' named entity 'DENDRITIC CELLS' named entity 'FUNCTIONAL' named entity 'TARGET' named entity 'MOUSE BONE MARROW' named entity 'MICRORNAS' named entity 'ROLES' named entity 'FULLY' named entity 'DIFFERENTIATION' named entity 'CRITICAL' named entity 'MIRNAS' named entity 'NEGATIVE REGULATOR' named entity 'HSCS' named entity 'SPECIFIC' named entity 'MATURE' named entity 'DIFFERENT' named entity 'HISTONE MODIFICATION' named entity 'EPIGENETIC' named entity 'GENERATE' named entity 'REGULATION' named entity 'REGULATORY' named entity 'STAGE' named entity 'MAINTAIN' named entity 'EXPRESSION' named entity 'RESULTS' named entity 'PROVIDE' named entity 'PRODUCING' named entity 'IMMATURE' named entity 'IDENTIFIED' named entity 'PROMOTE' named entity 'NUMEROUS' named entity 'REGULATOR OF IMMUNE RESPONSE' named entity 'TGF-BETA' named entity 'DEVELOPMENT' named entity 'RESOURCE' named entity 'UPREGULATED' named entity 'IL-10' named entity 'INITIATE' named entity 'NOTCH1' named entity 'IN VIVO' named entity 'STEM CELL BIOLOGY' named entity 'DCS' named entity 'MIR' named entity 'DCs'

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