About: Coronaviruses Hijack the LC3-I-Positive EDEMosomes, ER-Derived Vesicles Exporting Short-Lived ERAD Regulators, for Replication

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About: Coronaviruses Hijack the LC3-I-Positive EDEMosomes, ER-Derived Vesicles Exporting Short-Lived ERAD Regulators, for Replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Coronaviruses Hijack the LC3-I-Positive EDEMosomes, ER-Derived Vesicles Exporting Short-Lived ERAD Regulators, for Replication
Creator	Bernasconi, Riccardo Bianchi, Siro Molinari, Maurizio Reggiori, Fulvio Ulasli, Mustafa Monastyrska, Iryna Calì, Tito De Haan, Cornelis Verheije, Monique
source	Elsevier; Medline; PMC
abstract	Coronaviruses (CoV), including SARS and mouse hepatitis virus (MHV), are enveloped RNA viruses that induce formation of double-membrane vesicles (DMVs) and target their replication and transcription complexes (RTCs) on the DMV-limiting membranes. The DMV biogenesis has been connected with the early secretory pathway. CoV-induced DMVs, however, lack conventional endoplasmic reticulum (ER) or Golgi protein markers, leaving their membrane origins in question. We show that MHV co-opts the host cell machinery for COPII-independent vesicular ER export of a short-living regulator of ER-associated degradation (ERAD), EDEM1, to derive cellular membranes for replication. MHV infection causes accumulation of EDEM1 and OS-9, another short-living ER chaperone, in the DMVs. DMVs are coated with the nonlipidated LC3/Atg8 autophagy marker. Downregulation of LC3, but not inactivation of host cell autophagy, protects cells from CoV infection. Our study identifies the host cellular pathway hijacked for supplying CoV replication membranes and describes an autophagy-independent role for nonlipidated LC3-I.
has issue date	2010-06-17(xsd:dateTime)
bibo:doi	10.1016/j.chom.2010.05.013
bibo:pmid	20542253
has license	no-cc
sha1sum (hex)	681dd338cc321be240c744707c893b5e35081ff9
schema:url	https://doi.org/10.1016/j.chom.2010.05.013
resource representing a document's title	Coronaviruses Hijack the LC3-I-Positive EDEMosomes, ER-Derived Vesicles Exporting Short-Lived ERAD Regulators, for Replication
has PubMed Central identifier	PMC7103375
has PubMed identifier	20542253
schema:publication	Cell Host Microbe
resource representing a document's body	covid:681dd338cc321be240c744707c893b5e35081ff9#body_text
is schema:about of	named entity 'export' named entity 'regulator' named entity 'hijacked' named entity 'viruses' named entity 'LC3' named entity 'REPLICATION' named entity 'DERIVED' named entity 'ERAD' named entity 'INFECTION' named entity 'MEMBRANE' named entity 'BUT' named entity 'AUTOPHAGY' named entity 'CELLULAR' named entity 'LACK' named entity 'PROTEIN ' named entity 'MACHINERY' named entity 'MOUSE HEPATITIS VIRUS' named entity 'MARKERS' named entity 'OS-9' named entity 'CHAPERONE' named entity 'THEIR' named entity 'FORMATION' named entity 'LIVING' named entity 'ASSOCIATED' named entity 'COPII' named entity 'TRANSCRIPTION' named entity 'MEMBRANES' named entity 'BIOGENESIS' named entity 'REGULATORS' named entity 'SHORT' named entity 'LC3' named entity 'CORONAVIRUSES' named entity 'DEGRADATION' named entity 'SARS' named entity 'EXPORTING' named entity 'ER-' named entity 'VESICLES' named entity 'POSITIVE' named entity 'ENDOPLASMIC RETICULUM' named entity 'ROLE' named entity 'CONVENTIONAL' named entity 'EARLY' named entity 'SECRETORY PATHWAY' named entity 'LEAVING' named entity 'ER-' named entity 'EDEM1' named entity 'EXPORT' named entity 'TARGET' named entity 'LIMITING' named entity 'INDEPENDENT' named entity 'REGULATOR' named entity 'ORIGINS' named entity 'OUR' named entity 'LC3' named entity 'COATED' named entity 'VESICULAR' named entity 'CAUSES' named entity 'STUDY' named entity 'INCLUDING' named entity 'COMPLEXES' named entity 'INDUCE' named entity 'CELLS' named entity 'INACTIVATION' named entity 'HOST CELL' named entity 'HOST' named entity 'VESICLES' named entity 'SHORT' named entity 'CORONAVIRUSES' named entity 'SUPPLYING' named entity 'DOUBLE' named entity 'ACCUMULATION' named entity 'REPLICATION' named entity 'MARKER'

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