About: Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ-Dependent in a Coronavirus Model of Multiple Sclerosis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ-Dependent in a Coronavirus Model of Multiple Sclerosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ-Dependent in a Coronavirus Model of Multiple Sclerosis
Creator	Perlman, Stanley Anghelina, Daniela Dandekar, Ajai
Source	Elsevier
abstract	Mice infected with the coronavirus mouse hepatitis virus, strain JHM (JHM) develop a disease that shares many histological characteristics with multiple sclerosis. We previously demonstrated that JHM-infected mice that only have CD8 T cells specific for an epitope not in the virus develop demyelination on specific activation of these cells. Herein we show that this process of bystander T-cell-mediated demyelination is interferon-γ (IFN-γ)-dependent. The absence of IFN-γ abrogated demyelination but did not change T-cell infiltration or expression levels of inflammatory cytokines or chemokines in the spinal cord. These results are consistent with models in which IFN-γ contributes to CD8 T-cell-mediated demyelination by activation of macrophages/microglia, the final effector cells in the disease process.
has issue date	2004-02-29(xsd:dateTime)
bibo:doi	10.1016/s0002-9440(10)63126-4
has license	els-covid
sha1sum (hex)	68249d769e1926678af8d52d2484e36787e13525
schema:url	https://doi.org/10.1016/s0002-9440%2810%2963126-4
resource representing a document's title	Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ-Dependent in a Coronavirus Model of Multiple Sclerosis
schema:publication	The American Journal of Pathology
resource representing a document's body	covid:68249d769e1926678af8d52d2484e36787e13525#body_text
is schema:about of	named entity 'consistent' named entity 'MEDIATED' named entity 'DEPENDENT' named entity 'COMMUNICATION' named entity 'CD8' named entity 'INTERFERON' named entity 'EFFECTOR' named entity 'MACROPHAGES' named entity '90%' named entity 'ACTIVATION' named entity 'CHEMOKINES' named entity 'MEDIATED' named entity 'MULTIPLE SCLEROSIS' named entity 'CORONAVIRUS' named entity 'MODEL OF' named entity 'BYSTANDER' named entity 'SHORT' named entity 'DEMYELINATION' named entity 'RESULTS' named entity 'DISEASE PROCESS' named entity 'SPINAL CORD' named entity '90%' named entity 'T-CELL' named entity 'DEMYELINATION' named entity 'CELLS' named entity 'T-CELL' named entity 'IFN' named entity 'FINAL' named entity 'CD8' named entity 'THESE' named entity 'CONSISTENT WITH' named entity 'MODELS' named entity 'microglia' named entity 'effector cells' named entity 'CD8' named entity 'IFN' named entity 'microglia' named entity 'T-Cell' named entity 'Multiple Sclerosis' named entity 'Coronavirus' named entity 'Interferon' named entity 'hematoxylin and eosin' named entity 'transgenic' named entity 'CD8 T cells' named entity 'CD8 T cells' named entity 'peptide' named entity 'CNS' named entity 'IFN' named entity 'demyelinating lesions' named entity 'IFN' named entity 'CD8' named entity 'disability' named entity 'mice' named entity 'CD8 T cells' named entity 'TNF' named entity 'IFN' named entity 'ImageJ' named entity 'APCs' named entity 'CD8 T cells' named entity 'macrophage' named entity 'demyelination' named entity 'demyelination' named entity 'IFN' named entity 'TNF' named entity 'demyelination' named entity 'interact' named entity 'myelin' named entity 'axons' named entity 'infection' named entity 'demyelination' named entity 'CNS' named entity 'CD8 T cells' named entity 'chemokine' named entity 'rat' named entity 'T7 RNA polymerase' named entity 'IgG' named entity 'microglia' named entity 'CD8 T cells' named entity 'chemokine' named entity 'protein' named entity 'IFN' named entity 'microglia'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software