About: Quantitative Temporal in Vivo Proteomics Deciphers the Transition of Virus-Driven Myeloid Cells into M2 Macrophages

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About: Quantitative Temporal in Vivo Proteomics Deciphers the Transition of Virus-Driven Myeloid Cells into M2 Macrophages Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Quantitative Temporal in Vivo Proteomics Deciphers the Transition of Virus-Driven Myeloid Cells into M2 Macrophages
Creator	Lee, Patrick Weekes, Michael Almasi, Shekoufeh Clements, Derek Gujar, Shashi Gygi, Steven Helson, Erin Holay, Namit Kennedy, Barry Kim, Youra Konda, Prathyusha Murphy, John Paulo, Joao Sharif, Tanveer Sterea, Andra
Source	Medline; PMC
abstract	[Image: see text] Myeloid cells play a central role in the context of viral eradication, yet precisely how these cells differentiate throughout the course of acute infections is poorly understood. In this study, we have developed a novel quantitative temporal in vivo proteomics (QTiPs) platform to capture proteomic signatures of temporally transitioning virus-driven myeloid cells directly in situ, thus taking into consideration host–virus interactions throughout the course of an infection. QTiPs, in combination with phenotypic, functional, and metabolic analyses, elucidated a pivotal role for inflammatory CD11b(+), Ly6G(–), Ly6C(high-low) cells in antiviral immune response and viral clearance. Most importantly, the time-resolved QTiPs data set showed the transition of CD11b(+), Ly6G(–), Ly6C(high-low) cells into M2-like macrophages, which displayed increased antigen-presentation capacities and bioenergetic demands late in infection. We elucidated the pivotal role of myeloid cells in virus clearance and show how these cells phenotypically, functionally, and metabolically undergo a timely transition from inflammatory to M2-like macrophages in vivo. With respect to the growing appreciation for in vivo examination of viral–host interactions and for the role of myeloid cells, this study elucidates the use of quantitative proteomics to reveal the role and response of distinct immune cell populations throughout the course of virus infection.
has issue date	2017-08-03(xsd:dateTime)
bibo:doi	10.1021/acs.jproteome.7b00425
bibo:pmid	28768414
has license	no-cc
sha1sum (hex)	685eba5fefce2d8dff007fa996ecf065e56da933
schema:url	https://doi.org/10.1021/acs.jproteome.7b00425
resource representing a document's title	Quantitative Temporal in Vivo Proteomics Deciphers the Transition of Virus-Driven Myeloid Cells into M2 Macrophages
has PubMed Central identifier	PMC5648240
has PubMed identifier	28768414
schema:publication	J Proteome Res
resource representing a document's body	covid:685eba5fefce2d8dff007fa996ecf065e56da933#body_text
is schema:about of	named entity 'myeloid' named entity 'infections' named entity 'antiviral' named entity 'Quantitative' named entity 'Myeloid' named entity 'USE OF' named entity 'CENTRAL' named entity 'NOVEL' named entity 'IN VIVO' named entity 'MYELOID CELLS' named entity 'LY6G' named entity 'SIGNATURES' named entity 'DEMANDS' named entity 'HOST' named entity 'HIGH-LOW' named entity 'VIRUS INFECTION' named entity 'VIRAL CLEARANCE' named entity 'INTERACTIONS' named entity 'VIRUS' named entity 'ROLE' named entity 'GROWING' named entity 'PROTEOMIC' named entity 'IN SITU' named entity 'METABOLIC' named entity 'DIFFERENTIATE' named entity 'QUANTITATIVE PROTEOMICS' named entity 'TEMPORAL' named entity 'MYELOID CELLS' named entity 'DISPLAYED' named entity 'MACROPHAGES' named entity 'VIRAL' named entity 'CONSIDERATION' named entity 'CD11B' named entity 'ERADICATION' named entity 'INCREASED' named entity 'DRIVEN' named entity 'PROTEOMICS' named entity 'ACUTE INFECTIONS' named entity 'UNDERSTOOD' named entity 'TIMELY' named entity 'PROTEOMICS' named entity 'POPULATIONS' named entity 'HOW' named entity 'DRIVEN' named entity 'VIRUS' named entity 'TEMPORAL' named entity 'MACROPHAGES' named entity 'PLAY' named entity 'RESPECT' named entity 'REVEAL' named entity 'LATE' named entity 'RESOLVED' named entity 'QUANTITATIVE' named entity 'APPRECIATION' named entity 'THESE' named entity 'TRANSITION' named entity 'RESPONSE' named entity 'COMBINATION' named entity 'DISTINCT' named entity 'COURSE' named entity 'LIKE' named entity 'CONTEXT' named entity 'INFECTION' named entity 'HAVE' named entity 'DATA SET' named entity 'VIRUS CLEARANCE' named entity 'TAKING'

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