About: The immunomodulatory CEA cell adhesion molecule 6 (CEACAM6/CD66c) is a candidate receptor for the influenza A virus

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About: The immunomodulatory CEA cell adhesion molecule 6 (CEACAM6/CD66c) is a candidate receptor for the influenza A virus Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The immunomodulatory CEA cell adhesion molecule 6 (CEACAM6/CD66c) is a candidate receptor for the influenza A virus
Creator	Chhibber, Sanjay Gaur, Pratibha Lal, Sunil Waris, Gulam Ahmad, Imtiyaz Ansari, Ahmed Chakravarty, Chandrani Kumar Verma, Dileep Nehal, Naila Rahman, Shah Sellathanby, Shanmugaapriya Wirth, Dagmar
Source	BioRxiv; MedRxiv
abstract	To establish a productive infection in host cells, viruses often use one or multiple host membrane glycoprotein as their receptors. For Influenza A virus (IAV) such a glycoprotein receptor has not been described, to date. Here we show that IAV is using the host membrane glycoprotein CD66c as a receptor for entry into human epithelial lung cells. Neuraminidase (NA), a viral spike protein binds to CD66c on the cell surface during IAV entry into the host cells. Lung cells overexpressing CD66c showed an increase in virus binding and subsequent entry into the cell. Upon comparison, CD66c demonstrated higher binding capacity than other membrane glycoproteins (EGFR and DC-SIGN) reported earlier to facilitate IAV entry into host cells. siRNA mediated knockdown of CD66c from lung cells inhibited virus binding on cell surface and entry into cells. Blocking CD66c by antibody on the cell surface resulted in decreased virus entry. We found CD66c is a specific glycoprotein receptor for influenza A virus that did not affect entry of non-IAV RNA virus (Hepatitis C virus). Finally, IAV pre-incubated with recombinant CD66c protein when administered intranasally in mice showed decreased cytopathic effects in mice lungs. This publication is the first to report CD66c (CEACAM6) as a glycoprotein receptor for Influenza A virus. Significance Statement Cells are enclosed by a semipermeable membrane that allows selective exchange of biomolecules between cells and their surroundings. A set of specialized proteins in this semipermeable membrane, work like gatekeepers to the cell and regulate entry of these biomolecules. One class of such surface proteins is termed as receptors. Viruses bind to one or more of these receptors and manipulate gatekeepers for their own successful entry into host-cells. A membrane protein that influenza A virus (Flu virus) uses for entry into the cells was not discovered till date. This study reports for the first time, a receptor for influenza A virus, that was sought after by researchers for decades. The viral receptor is a promising target that can be used to inhibit virus entry into host cells.
has issue date	2017-01-30(xsd:dateTime)
bibo:doi	10.1101/104026
has license	biorxiv
sha1sum (hex)	68b45eb2b2741f583bd4772f08f47c7e81ad2215
schema:url	https://doi.org/10.1101/104026
resource representing a document's title	The immunomodulatory CEA cell adhesion molecule 6 (CEACAM6/CD66c) is a candidate receptor for the influenza A virus
schema:publication	bioRxiv
resource representing a document's body	covid:68b45eb2b2741f583bd4772f08f47c7e81ad2215#body_text
is schema:about of	named entity 'For' named entity 'lung' named entity 'receptor' named entity 'protein' named entity 'influenza A virus' named entity 'surface' named entity 'IAV' named entity 'viral' named entity 'Influenza A virus' named entity 'CD66c' named entity 'IAV' named entity 'epithelial' named entity 'CEA' named entity 'receptor' named entity 'IAV' named entity 'DC-SIGN' named entity 'immunofluorescence assay' named entity 'CD66c' named entity 'immune response' named entity 'cell adhesion molecules' named entity 'IAV' named entity 'recombinant' named entity 'DC-SIGN' named entity 'DC-SIGN' named entity 'NS3' named entity 'viruses' named entity 'CD66c' named entity 'viruses' named entity 'CD66c' named entity 'pathogen' named entity 'IAV' named entity 'HCV' named entity 'virus entry' named entity 'CD66c' named entity 'CD66c' named entity 'recombinant' named entity 'CD66c' named entity 'Rabies' named entity 'EGFR' named entity 'influenza virus' named entity 'CD66c' named entity 'EGFR' named entity 'Influenza A virus' named entity 'mammalian cells' named entity 'CD66c' named entity 'virus' named entity 'glycoprotein' named entity 'Sialyl-Lewis X' named entity 'clathrin' named entity 'bronchial epithelial cells' named entity 'virus entry' named entity 'EGFR' named entity 'bacteria' named entity 'Reovirus' named entity 'endogenous' named entity 'influenza' named entity 'IAV' named entity 'influenza infection' named entity 'CD66c' named entity 'CD66c' named entity 'IAV' named entity 'expression levels' named entity 'IAV' named entity 'DC-SIGN' named entity 'viral entry' named entity 'viruses' named entity 'infection' named entity 'virus' named entity 'virus' named entity 'protein receptor' named entity 'virus' named entity 'inoculation' named entity 'virus'

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