About: ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition

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About: ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition
Creator	Guan, Li Collins, Francis Falchi, Mario Bell, Jordana Boehnke, Michael Bonnycastle, Lori Brotman, Sarah El-Sayed Moustafa, Julia Erdos, Michael Jackson, Anne Koistinen, Heikki Laakso, Markku Lakka, Timo Mohlke, Karen Narisu, Narisu Pajukanta, Päivi Parker, Stephen Roberts, Amy Scott, Laura Small, Kerrin Stringham, Heather Tuomilehto, Jaakko Villicaña, Sergio Welch, Ryan Yan, Tingfen Zito, Antonino
Source	MedRxiv; Medline; PMC
abstract	COVID-19 severity has varied widely, with demographic and cardio-metabolic factors increasing risk of severe reactions to SARS-CoV-2 infection, but the underlying mechanisms for this remain uncertain. We investigated phenotypic and genetic factors associated with subcutaneous adipose tissue expression of Angiotensin I Converting Enzyme 2 (ACE2), which has been shown to act as a receptor for SARS-CoV-2 cellular entry. In a meta-analysis of three independent studies including up to 1,471 participants, lower adipose tissue ACE2 expression was associated with adverse cardio-metabolic health indices including type 2 diabetes (T2D) and obesity status, higher serum fasting insulin and BMI, and lower serum HDL levels (P<5.32×10(−4)). ACE2 expression levels were also associated with estimated proportions of cell types in adipose tissue; lower ACE2 expression was associated with a lower proportion of microvascular endothelial cells (P=4.25×10(−4)) and higher macrophage proportion (P=2.74×10(−5)), suggesting a link to inflammation. Despite an estimated heritability of 32%, we did not identify any proximal or distal genetic variants (eQTLs) associated with adipose tissue ACE2 expression. Our results demonstrate that at-risk individuals have lower background ACE2 levels in this highly relevant tissue. Further studies will be required to establish how this may contribute to increased COVID-19 severity.
has issue date	2020-08-14(xsd:dateTime)
bibo:doi	10.1101/2020.08.11.20171108
bibo:pmid	32817962
has license	cc-by
sha1sum (hex)	68c798ac9c27d39356e27c64c2fbcffde3f49f8b
schema:url	https://doi.org/10.1101/2020.08.11.20171108
resource representing a document's title	ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition
has PubMed Central identifier	PMC7430606
has PubMed identifier	32817962
schema:publication	medRxiv
resource representing a document's body	covid:68c798ac9c27d39356e27c64c2fbcffde3f49f8b#body_text
is schema:about of	named entity 'expression' named entity 'adipose tissue' named entity 'risk factors' named entity 'ACE2' named entity 'adipose tissue' named entity 'metabolic' named entity 'cofactor' named entity 'SARS-CoV-2' named entity 'TwinsUK' named entity 'TMPRSS2' named entity 'correlation' named entity 'ACE2' named entity 'lymphoblastoid cell' named entity 'ACE2' named entity 'adipose' named entity 'lymphoblastoid cell' named entity 'TwinsUK' named entity 'TwinsUK' named entity 'Insulin' named entity 'ACE2' named entity 'regulation of blood pressure' named entity 'TMPRSS2' named entity 'correlation' named entity 'ACE2' named entity 'transmembrane protease, serine 2' named entity 'adipose tissue' named entity 'Fasting' named entity 'enzyme' named entity 'BMI' named entity 'cell type' named entity 'COVID' named entity 'risk factors' named entity 'ACE2' named entity 'COVID-19' named entity 'metabolic' named entity 'cell type' named entity 'cardio' named entity 'CELL TYPE' named entity 'ADIPOSE TISSUE' named entity 'METABOLIC' named entity 'EXPRESSION' named entity 'RISK FACTORS' named entity 'ASSOCIATED WITH' named entity 'COMPOSITION' named entity 'COVID-19' named entity 'ACE2'
is part of of	covid:68c798ac9c27d39356e27c64c2fbcffde3f49f8b#body_text ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition COVID-19 severity has varied widely, with demographic and cardio-metabolic factors increasing risk of severe reactions to SARS-CoV-2 infection, but the underlying mechanisms for this remain uncertain. We investigated phenotypic and genetic factors associated with subcutaneous adipose tissue expression of Angiotensin I Converting Enzyme 2 (ACE2), which has been shown to act as a receptor for SARS-CoV-2 cellular entry. In a meta-analysis of three independent studies including up to 1,471 participants, lower adipose tissue ACE2 expression was associated with adverse cardio-metabolic health indices including type 2 diabetes (T2D) and obesity status, higher serum fasting insulin and BMI, and lower serum HDL levels (P<5.32×10(−4)). ACE2 expression levels were also associated with estimated proportions of cell types in adipose tissue; lower ACE2 expression was associated with a lower proportion of microvascular endothelial cells (P=4.25×10(−4)) and higher macrophage proportion (P=2.74×10(−5)), suggesting a link to inflammation. Despite an estimated heritability of 32%, we did not identify any proximal or distal genetic variants (eQTLs) associated with adipose tissue ACE2 expression. Our results demonstrate that at-risk individuals have lower background ACE2 levels in this highly relevant tissue. Further studies will be required to establish how this may contribute to increased COVID-19 severity.

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