About: Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectin

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About: Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectin
Creator	Dworkin, L Gong, R Rifai, A
Source	Elsevier; Medline; PMC
abstract	Vascular endothelial activation, marked by de novo expression of E-selectin, is an early and essential event in the process of leukocyte extravasation and inflammation. Evidence suggests that hepatocyte growth factor (HGF) ameliorates inflammation in animal models of renal disease, implying that HGF might inhibit specific components of the inflammatory response. This study examined the effect of HGF on endothelial E-selectin expression in acute inflammation induced by tumor necrosis factor (TNF)-α. In vitro, HGF suppressed TNF-α-induced cell surface expression of E-selectin in human umbilical vein endothelial cells (HUVEC) and inhibited E-selectin mediated monocytic adhesion to endothelial monolayers. HGF activated phosphatidylinositol 3-kinase (PI3K)–Akt that in turn inhibited its downstream transducer glycogen synthase kinase (GSK)3. Blockade of the PI3K–Akt pathway with specific inhibitors abrogated HGF induced inhibitory phosphorylation of GSK3 and suppression of E-selectin. In addition, selective inhibition of GSK3 activity by lithium suppressed TNF-α-induced E-selectin expression and monocytic adhesion, reminiscent of the action of HGF. Moreover, ectopic expression of an uninhibitable mutant GSK3β, in which the regulatory serine-9 is replaced by alanine, abolished HGF's suppressive effect on endothelial E-selectin. In vivo, administration of exogenous HGF reduced endothelial expression of E-selectin induced by bolus injection of TNF-α. This was associated with less sequestration of circulating fluorescence-labeled macrophages in the kidney. These findings suggest that HGF ameliorates acute renal inflammation in part by downregulating E-selectin mediated macrophage adhesion to the inflamed endothelium.
has issue date	2006-04-01(xsd:dateTime)
bibo:doi	10.1038/sj.ki.5000246
bibo:pmid	16501492
has license	els-covid
sha1sum (hex)	68d56c01c685d14f8103aba94c73a6fa88103f73
schema:url	https://doi.org/10.1038/sj.ki.5000246
resource representing a document's title	Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectin
has PubMed Central identifier	PMC7126584
has PubMed identifier	16501492
schema:publication	Kidney International
resource representing a document's body	covid:68d56c01c685d14f8103aba94c73a6fa88103f73#body_text
is schema:about of	named entity 'selective' named entity 'GSK' named entity 'E-selectin' named entity 'E-selectin' named entity 'sequestration' named entity 'mediated' named entity 'downregulating' named entity 'serine' covid:arg/68d56c01c685d14f8103aba94c73a6fa88103f73 named entity 'Akt' named entity 'induced' named entity 'reminiscent' named entity 'TNF' named entity 'E-selectin' named entity 'leukocyte extravasation' named entity 'inhibition' named entity 'specific' named entity 'endothelial' named entity 'mediated' named entity 'Cell culture' named entity 'flow cytometry' named entity 'lithium' named entity 'Sprague-Dawley' named entity 'inflammatory reaction' named entity 'GSK3b' named entity 'adhesion' named entity 'immunocytochemistry' named entity 'fluorescence' named entity 'plasmid' named entity 'nuclei' named entity 'Mek-Erk' named entity 'endothelium' named entity 'monocytic' named entity 'These' named entity 'specific' named entity 'acute inflammation' named entity 'activated' named entity 'expression' named entity 'GSK3' named entity 'E-selectin' named entity 'HGF' named entity 'E-selectin' named entity 'ectopic expression' named entity 'E-selectin' named entity 'HGF' named entity 'TNF-a' named entity 'macrophages' named entity 'endothelial' named entity 'alanine' named entity 'E-selectin' named entity 'HGF' named entity 'endothelial' named entity 'phosphorylation' named entity 'HUVEC' named entity 'E-selectin' named entity 'Hepatocyte growth factor' named entity 'HGF' named entity 'GSK3b' named entity 'monocyte' named entity 'endothelial' named entity 'cell lysates' named entity 'TNF-a' named entity 'University of Toronto' named entity 'HGF' named entity 'selectins' named entity 'secondary antibody' named entity 'transfection' named entity 'FACS' named entity 'E-selectin' named entity 'monocyte' named entity 'E-selectin' named entity 'HUVEC' named entity 'endothelial activation' named entity 'pixel density' named entity 'Becton Dickinson' named entity 'recombinant' named entity 'HGF' named entity 'primary antibody' named entity 'mAb'

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