About: Single-cell RNA expression profiling of ACE2,thereceptor of SARS-CoV-2

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Single-cell RNA expression profiling of ACE2,thereceptor of SARS-CoV-2
Creator	Zhao, Yu Ma, Yu Wang, Yujia Zhao, Zixian Zhou, Yueqing Zuo, Wei
Source	BioRxiv; MedRxiv
abstract	A novel coronavirus SARS-CoV-2 was identified in Wuhan, Hubei Province, China in December of 2019. According to WHO report, this new coronavirus has resulted in 76,392 confirmed infections and 2,348 deaths in China by 22 February, 2020, with additional patients being identified in a rapidly growing number internationally. SARS-CoV-2 was reported to share the same receptor, Angiotensin-converting enzyme 2 (ACE2), with SARS-CoV. Here based on the public database and the state-of-the-art single-cell RNA-Seq technique, we analyzed the ACE2 RNA expression profile in the normal human lungs. The result indicates that the ACE2 virus receptor expression is concentrated in a small population of type II alveolar cells (AT2). Surprisingly, we found that this population of ACE2-expressing AT2 also highly expressed many other genes that positively regulating viral entry, reproduction and transmission. This study provides a biological background for the epidemic investigation of the COVID-19, and could be informative for future anti-ACE2 therapeutic strategy development.
has issue date	2020-01-26(xsd:dateTime)
bibo:doi	10.1101/2020.01.26.919985
has license	medrxiv
sha1sum (hex)	68e509d42a7d3349550512d80eca4e2b2123613f
schema:url	https://doi.org/10.1101/2020.01.26.919985
resource representing a document's title	Single-cell RNA expression profiling of ACE2,thereceptor of SARS-CoV-2
schema:publication	bioRxiv
resource representing a document's body	covid:68e509d42a7d3349550512d80eca4e2b2123613f#body_text
is schema:about of	named entity 'internationally' named entity 'SARS-Cov' named entity 'SHARE' named entity 'ACE2' named entity 'ADDITIONAL' named entity 'CHINA' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'IDENTIFIED' named entity 'RAPIDLY' named entity '2019' named entity 'RECEPTOR' named entity 'CELL' named entity 'WUHAN' named entity 'RNA EXPRESSION' named entity 'WUHAN' named entity 'EXPRESSION PROFILING' named entity 'DISEASE' named entity 'SARS-COV' named entity 'CASES' named entity 'LETHAL' named entity 'HUBEI PROVINCE' named entity 'REPORTED' named entity 'GROWING' named entity 'BEING' named entity 'PATIENTS' named entity 'RECEPTOR' named entity '2019-NCOV' named entity 'SINGLE' named entity 'NOVEL CORONAVIRUS' named entity 'NEW' named entity '2019-NCOV' named entity 'DECEMBER' named entity 'NUMBER' named entity 'CORONAVIRUS' named entity 'coronavirus' named entity '2019' named entity 'Angiotensin-converting enzyme 2' named entity 'Hubei Province' named entity 'identified' named entity 'ACE2' named entity 'SARS-Cov' named entity 'coronavirus' named entity 'China' named entity '2019-nCov' named entity 'expression profiling' named entity '2019-nCov' named entity 'Wuhan' named entity 'ACE2' named entity 'lung' named entity 'virus' named entity 'scRNA-Seq' named entity 'lung' named entity 'infection disease' named entity 'human lung' named entity 'ACE2' named entity '2019-nCov' named entity 'ACE2' named entity 'GSN' named entity 'preprint' named entity 'SARS-Cov' named entity 'preprint' named entity 'preprint' named entity 'ACE2' named entity 'Asian' named entity '2019-nCov' named entity 'phylogenetic' named entity 'Asian' named entity 'airway' named entity 'DAG1' named entity 'receptor' named entity 'therapeutic strategies' named entity 'Seurat' named entity 'heterogeneity' named entity 'spike proteins' named entity 'receptor' named entity 'tSNE' named entity 'lungs' named entity 'lung' named entity 'TRIM27'

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