About: Human cytomegalovirus in the pancreas of patients with type 2 diabetes: Is there a relation to clinical features, mRNA and protein expression of insulin, somatostatin, and MHC class II?

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About: Human cytomegalovirus in the pancreas of patients with type 2 diabetes: Is there a relation to clinical features, mRNA and protein expression of insulin, somatostatin, and MHC class II? Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human cytomegalovirus in the pancreas of patients with type 2 diabetes: Is there a relation to clinical features, mRNA and protein expression of insulin, somatostatin, and MHC class II?
Creator	Oldstone, M Bergstrome, B Kl6ppel, G Lijhr, M Maekawa, R
Source	PMC
abstract	Human cytomegalovirus (HCMV) was recently demonstrated in the pancreas of about half the patients with type 2 diabetes mellitus in the absence of mumps, rubella or Coxsackie B virus. The present study addresses the question as to whether type 2 diabetes with an HCMV-positive pancreas differs from those with HCMV-negative pancreases with respect to age, sex, treatment, duration of disease, volume densities of B-cells and D-cells, mRNA levels of insulin and somatostatin, islet amyloid peptide deposits and major histocompatibility complex (MHC) class I and class II gene transcription, and protein expression. HCMV-positive type 2 diabetic patients showed a tendency towards a shorter duration of disease and significantly increased levels of MHC class II on RNA. In addition, expression of MHC class II product (HLA-DR) was identified in duct epithelial cells and/or islet cells in 9 diabetic pancreases and in 2 non-diabetic glands. No MHC class I expression could be detected. No other clinical differences between HCMV-positive and HCMV-negative glands were found. All 10 HCMV-positive diabetics showed a strong expression of MHC class II mRN in the pancreas. By immunocytochemistry, 4 of 10 demonstrated expression on the islets; three of ten also expressed MHC DRβ on ductal cells. This finding might be related to the viral infection, as only 2 of the 9 HCMV-negative patients were HLA-DRβ positive and none of the non-diabetic controls showed increased levels of MHC class II mRNA. These data suggest that HCMV infection in the pancreas is associated with type 2 diabetes. However, no conclusions as to a role of this virus in the aetiopathology of type 2 diabetes can be drawn at present.
has issue date	1992-01-01(xsd:dateTime)
bibo:doi	10.1007/bf01606908
bibo:pmid	1360719
has license	no-cc
sha1sum (hex)	68e6271532854e6fc03e80a9f0e2442a36a6350e
schema:url	https://doi.org/10.1007/bf01606908
resource representing a document's title	Human cytomegalovirus in the pancreas of patients with type 2 diabetes: Is there a relation to clinical features, mRNA and protein expression of insulin, somatostatin, and MHC class II?
has PubMed Central identifier	PMC7087593
has PubMed identifier	1360719
schema:publication	Virchows Arch A Pathol Anat Histopathol
resource representing a document's body	covid:68e6271532854e6fc03e80a9f0e2442a36a6350e#body_text
is schema:about of	named entity 'addition' named entity 'amyloid' named entity 'HCMV' named entity 'expressed' named entity 'peptide' named entity 'diabetic' named entity 'patients' named entity 'pancreas' named entity 'HUMAN CYTOMEGALOVIRUS' named entity 'MHC CLASS II' named entity 'COXSACKIE B VIRUS' named entity 'MHC' named entity 'RNA' named entity 'HALF' named entity 'CLASS II GENE' named entity 'PRESENT' named entity 'MHC CLASS II' named entity 'MHC CLASS I' named entity 'PRODUCT' named entity 'ABOUT' named entity 'TYPE 2 DIABETES MELLITUS' named entity 'IDENTIFIED' named entity 'VIRAL INFECTION' named entity 'DATA' named entity 'PROTEIN EXPRESSION' named entity 'HUMAN CYTOMEGALOVIRUS' named entity 'DIABETIC' named entity 'WITH TYPE' named entity 'VOLUME' named entity 'HCMV' named entity 'STRONG' named entity 'LEVELS' named entity 'MUMPS' named entity 'MRNA' named entity 'TYPE 2 DIABETES' named entity 'THESE' named entity 'RESPECT' named entity 'ISLET' named entity 'ANATOMY' named entity 'WITH TYPE' named entity 'INSULIN' named entity 'HISTOPATHOLOGY' named entity 'RELATION' named entity 'CLINICAL' named entity 'TYPE 2 DIABETES' named entity 'DENSITIES' named entity 'DEPOSITS' named entity 'RUBELLA' named entity 'ASSOCIATED WITH' named entity 'DURATION OF DISEASE' named entity 'SUGGEST' named entity 'NEGATIVE' named entity 'AGE' named entity 'DUCT' named entity 'B-CELLS' named entity 'NON-' named entity 'CLASS I' named entity 'CONCLUSIONS' named entity 'HCMV INFECTION' named entity 'ROLE' named entity 'SEX' named entity 'VIRUS' named entity 'SOMATOSTATIN' named entity 'DEMONSTRATED' named entity 'RELATED' named entity 'STUDY' named entity 'FINDING' named entity 'ADDRESSES' named entity 'PANCREAS' named entity 'PROTEIN EXPRESSION' named entity 'PATIENTS' named entity 'MRNA' named entity 'PATHOLOGICAL' named entity 'HLA-DR' named entity 'POSITIVE' named entity 'GLANDS' named entity 'ISLET CELLS'

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