About: Pathological Findings in the Testes of COVID-19 Patients: Clinical Implications

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathological Findings in the Testes of COVID-19 Patients: Clinical Implications
Creator	Yang, Ming Zhou, Ming Zhou, Li He, Jun Li, Xiang Zhou, M Luo, Fan Ma, Lin Chen, Shuo Su, Hua Cao, Qin Fan, Jun Huang, Bo Li, He Nie, Xiu Chang, Xiao-Na Chen, Ya-Jun Li, Xue-Fei Luo, Dan-Ju Zhong, Huang Zhong, Jing-Min Zhou, Jun-Jie
Source	Elsevier; Medline; PMC
abstract	Abstract Background Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), involves multiple organs. Testicular involvement is largely unknown. Objective To determine the pathological changes and whether SARS-CoV-2 can be detected in the testes of deceased COVID-19 patients. Design, setting, and participants Postmortem examination of the testes from 12 COVID-19 patients was performed using light and electron microscopy, and immunohistochemistry for lymphocytic and histiocytic markers. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the virus in testicular tissue. Outcome measurements and statistical analysis Seminiferous tubular injury was assessed as none, mild, moderate, or severe according to the extent of tubular damage. Leydig cells in the interstitium were counted in ten 400× microscopy fields. Results and limitations Microscopically, Sertoli cells showed swelling, vacuolation and cytoplasmic rarefaction, detachment from tubular basement membranes, and loss and sloughing into lumens of the intratubular cell mass. Two, five, and four of 11 cases showed mild, moderate, and severe injury, respectively. The mean number of Leydig cells in COVID-19 testes was significantly lower than in the control group (2.2 vs 7.8, p < 0.001). In the interstitium there was edema and mild inflammatory infiltrates composed of T lymphocytes and histiocytes. Transmission EM did not identify viral particles in three cases. RT-PCR detected the virus in one of 12 cases. Conclusions Testes from COVID-19 patients exhibited significant seminiferous tubular injury, reduced Leydig cells, and mild lymphocytic inflammation. We found no evidence of SARS-CoV-2 virus in the testes in the majority (90%) of the cases by RT-PCR, and in none by electron microscopy. These findings can provide evidence-based guidance for sperm donation and inform management strategies to mitigate the risk of testicular injury during the COVID-19 disease course. Patient summary We examined the testes of deceased COVID-19 patients. We found significant damage to the testicular parenchyma. However, virus was not detected in testes in the majority of cases.
has issue date	2020-05-31(xsd:dateTime)
bibo:doi	10.1016/j.euf.2020.05.009
bibo:pmid	32563676
has license	els-covid
sha1sum (hex)	6965c397de2fdd929fcfae773e1fb5ad90e65cf7
schema:url	https://doi.org/10.1016/j.euf.2020.05.009
resource representing a document's title	Pathological Findings in the Testes of COVID-19 Patients: Clinical Implications
has PubMed Central identifier	PMC7261470
has PubMed identifier	32563676
schema:publication	Eur Urol Focus
resource representing a document's body	covid:6965c397de2fdd929fcfae773e1fb5ad90e65cf7#body_text
is schema:about of	named entity 'management' named entity 'COVID-19' named entity 'pathological' named entity 'played' named entity 'histiocytes' named entity 'injury' named entity 'sperm donation' named entity 'Pathological' named entity 'TESTICULAR INJURY' named entity 'VACUOLATION' named entity 'EDEMA' named entity 'DETACHMENT' named entity 'UNKNOWN' named entity 'TESTICULAR TISSUE' named entity 'COVID-19 DISEASE COURSE' named entity 'BASED' named entity 'POLYMERASE CHAIN REACTION' named entity 'POSTMORTEM EXAMINATION' named entity 'CELL MASS' named entity 'LOSS' named entity 'VIRUS' named entity 'SEVERE' named entity 'CORONAVIRUS DISEASE 2019' named entity 'INTERPRETATION' named entity 'PATIENTS' named entity 'Postmortem examination' named entity 'light' named entity 'SARS-CoV-2' named entity 'data' named entity 'conduct' named entity 'cases' named entity 'RT-PCR' named entity 'Leydig cells' named entity 'patients' named entity 'participants' named entity 'statistical analysis' named entity 'cytoplasmic' named entity 'patients' named entity 'particles' named entity 'mild' named entity 'tissue' named entity 'cell' named entity 'virus' named entity 'inflammation' named entity 'reduced' named entity 'testes' named entity 'counted' named entity 'Journal' named entity 'COVID' named entity 'Testicular involvement' named entity 'vacuolation' named entity 'COVID' named entity 'RT-PCR' named entity 'Leydig cells' named entity 'viral particles' named entity 'cytoplasmic' named entity 'Testes' named entity 'Leydig cells' named entity 'electron microscopy' named entity 'COVID'

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