About: Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients

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About: Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients
Creator	Bie, Mengjun Zhao, Xuemin
Source	PMC
abstract	BACKGROUND: Acute aortic dissection (AAD) is an acute life-threatening cardiovascular disease, which is frequently complicated with oxygenation impairment (OI). We aim to investigate predictors of the development of OI in the patients with AAD. METHODS: We retrospectively collected clinical data of AAD in hypertensive patients from July 2012 to March 2020. The patients included in this study were divided into OI (+) group (oxygenation index≤200) and OI (−) group (oxygenation index> 200). Both groups were compared according to demographic and clinical characteristics, and laboratory findings. Characteristics of hypertension in the patients with AAD were described. Predictors for the development of OI were assessed. And cutoff values were determined by receiver operating characteristics (ROC) curve. RESULTS: A total of 208 patients were included in this study and the incidence of OI was 32.2%. In OI (+) group, patients had significantly higher peak body temperature (37.85 ± 0.60 vs 37.64 ± 0.44 °C, P = .005), higher levels of CRP (42.70 ± 28.27 vs 13.90 ± 18.70 mg/L, P = .000) and procalcitonin (1.07 ± 3.92 vs 0.31 ± 0.77μg/L, P = .027), and lower levels of albumin (34.21 ± 5.65 vs 37.73 ± 4.70 g/L, P = .000). Spearman’s rank correlation test showed that the minimum oxygenation index was positively correlated with albumin, and was negatively correlated with the peak body temperature, serum CRP, procalcitonin, BNP and troponin. The stepwise multiple linear regression analysis showed that the peak body temperature, serum CRP and albumin were independently associated with development of OI. An optimal cutoff value for CRP for predicting OI was ≥9.20 mg/L, with a sensitivity of 91.0% and a specificity of 61.0%. CONCLUSIONS: The peak body temperature, serum CRP and albumin were independent predictors of OI development in the patients with AAD. The serum CRP on admission≥9.20 mg/L might be a valuable and reliable indicator in predicting the development of OI.
has issue date	2020-08-10(xsd:dateTime)
bibo:doi	10.1186/s12872-020-01652-5
has license	cc-by
sha1sum (hex)	69c55fc67b309790f3effb53c07d075a95699f13
schema:url	https://doi.org/10.1186/s12872-020-01652-5
resource representing a document's title	Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients
has PubMed Central identifier	PMC7416810
schema:publication	BMC Cardiovasc Disord
resource representing a document's body	covid:69c55fc67b309790f3effb53c07d075a95699f13#body_text
is schema:about of	named entity 'oxygenation' named entity 'determined' named entity 'demographic' named entity 'complicated' named entity 'ACUTE AORTIC DISSECTION' named entity 'HYPERTENSIVE' named entity 'DIVIDED' named entity 'BACKGROUND' named entity 'GROUPS' named entity 'LABORATORY' named entity 'data' named entity 'retrospectively' named entity 'assessed' named entity 'cytokines' named entity 'arterial oxygen tension' named entity 'hypertension' named entity 'patients' named entity 'development' named entity 'operating' named entity 'clinical data' named entity 'patients' named entity 'lipid' named entity 'serum' named entity 'Blood samples' named entity 'medical records' named entity 'BNP' named entity 'hypertensive' named entity 'hypertensive' named entity 'standard deviation' named entity 'chronic inflammation' named entity 'inflammatory cascade' named entity 'inflammatory reactions' named entity 'hypertensive' named entity 'macrophages' named entity 'kidney function' named entity 'albumin' named entity 'medical records' named entity 'C-Reactive protein' named entity 'teaching hospital' named entity 'mice' named entity 'acute-phase protein' named entity 'procalcitonin' named entity 'rank correlation' named entity 'oxidative stress' named entity '36.5°C' named entity 'AUC' named entity '95% CI' named entity 'inflammatory markers' named entity 'life-threatening' named entity 'inflammatory response' named entity 'procalcitonin' named entity 'serum albumin levels' named entity 'sample size' named entity 'microvascular permeability' named entity 'albumin' named entity 'sensitivity and specificity' named entity 'CRP' named entity 'myocardial infarction' named entity 'Hypertensive' named entity 'albumin' named entity 'Marfan syndrome' named entity 'CRP' named entity 'statistical analysis' named entity 'blood pressure' named entity 'CRP' named entity 'medical ethics' named entity 'CRP' named entity 'hypertensive' named entity 'aortic dissection' named entity 'area under curve' named entity 'blood-brain barrier' named entity 'body temperatures' named entity 'mechanical ventilator' named entity 'prognostic factor' named entity 'SPSS' named entity 'peak body temperature' named entity 'clinical characteristics' named entity 'hypertension' named entity 'inflammation' named entity 'procalcitonin' named entity 'hypertensive' named entity 'CRP'

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