About: Comparison of the Laboratory Data Between Kawasaki Disease and Enterovirus After Intravenous Immunoglobulin Treatment

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparison of the Laboratory Data Between Kawasaki Disease and Enterovirus After Intravenous Immunoglobulin Treatment
Creator	Chang, Wei-Chiao Kuo, Ho-Chang Yu, Hong-Ren Yang, D Huang, Yi-Chuan Lin, Ying-Jui Kuender, • Lin, Li-Yan Yang, Tsung-Hsien
Source	PMC
abstract	Kawasaki disease (KD) is a systemic vasculitis of unknown etiology. The laboratory findings before and after intravenous immunoglobulin (IVIG) in KD have been discussed, but the characteristics of IVIG therapy still are unclear. This study aimed to compare laboratory data from patients with KD and enterovirus (EV) infection to evaluate the differences after IVIG therapy. The study enrolled 171 KD patients and 38 EV patients treated with a single dose of IVIG from 2003 to 2010. Laboratory data including total white blood cell counts (WBC) and hemoglobin (Hb), platelet, segment, lymphocyte, eosinophil, and monocyte levels were analyzed. Compared with the KD patients, the EV patients had higher Hb, lymphocyte, and monocyte levels and lower eosinophil levels before IVIG treatment (p < 0.05). After IVIG treatment, the KD patients had lower Hb and segment levels but higher platelet, lymphocyte, and eosinophil levels than the EV patients (p < 0.05). In the KD patients, the platelet, eosinophil, and monocyte levels increased after IVIG treatment, whereas Hb, WBC, and segment levels decreased significantly (p < 0.001). In the EV patients, eosinophil levels increased after IVIG treatment, whereas WBC and Hb levels decreased significantly (p < 0.05). The study results provide evidence that eosinophilia may be related to IVIG therapy in KD and EV patients. The KD patients had higher eosinophil levels both before and after IVIG therapy than the EV patients, which may have been due to the inflammatory mechanism of KD. The KD patients had higher platelet levels than the EV patients, suggesting that platelets are involved in the inflammatory response to KD.
has issue date	2012-03-25(xsd:dateTime)
bibo:doi	10.1007/s00246-012-0293-9
bibo:pmid	22447381
has license	no-cc
sha1sum (hex)	69f86b52667bfbb3fc2a6e8f19769634268d6faf
schema:url	https://doi.org/10.1007/s00246-012-0293-9
resource representing a document's title	Comparison of the Laboratory Data Between Kawasaki Disease and Enterovirus After Intravenous Immunoglobulin Treatment
has PubMed Central identifier	PMC7100730
has PubMed identifier	22447381
schema:publication	Pediatr Cardiol
resource representing a document's body	covid:69f86b52667bfbb3fc2a6e8f19769634268d6faf#body_text
is schema:about of	named entity 'This' named entity 'patients' named entity 'IVIG' named entity 'patients' named entity 'involved' named entity 'segment' named entity 'laboratory' named entity 'The' covid:arg/69f86b52667bfbb3fc2a6e8f19769634268d6faf named entity 'infection' named entity 'data' named entity 'patients' named entity 'Laboratory' named entity 'provide' named entity 'levels' named entity 'Disease' named entity 'WBC' named entity 'WBC' named entity 'monocyte' named entity 'IVIG therapy' named entity 'platelet' named entity 'IVIG' named entity 'IVIG' named entity 'platelet' named entity 'monocyte' named entity 'platelet' named entity 'Enterovirus' named entity 'Intravenous Immunoglobulin' named entity 'IVIG' named entity 'therapy' named entity 'IL-5' named entity 'eosinophils' named entity 'standard deviation' named entity 'interleukin (IL)-5' named entity 'oculomotor' named entity 'respiratory distress' named entity 'IL-5' named entity 'statistically significant' named entity 'coronary artery' named entity 'IVIG' named entity 'edema' named entity 'eosinophil' named entity 'Th2' named entity 'Institutional Review Board' named entity 'IVIG therapy' named entity 'ECP' named entity 'tachycardia' named entity 'fever' named entity 'IL-5' named entity 'IVIG' named entity 'eosinophilia' named entity 'fever' named entity 'infusion' named entity 'tumor necrosis factor-alpha' named entity 'lymphocyte' named entity 'IVIG' named entity 'IL-4' named entity 'platelet' named entity 'asthma' named entity 'eosinophils' named entity 'IVIG' named entity 'Th2' named entity 'IVIG' named entity 'eosinophils' named entity 'Aspirin' named entity 'eosinophil' named entity 'eosinophilia' named entity 'vasculitis' named entity 'pulmonary edema' named entity 'eosinophil' named entity 'IL-4' named entity 'IVIG therapy' named entity 'Kaohsiung Chang Gung Memorial Hospital'

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