About: Breaking Bad: How Viruses Subvert the Cell Cycle

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Breaking Bad: How Viruses Subvert the Cell Cycle
Creator	Bruzzone, Roberto Wang, Tian Qiu, Jianming Fan, Ying Sanyal, Sumana Liu, Zhengwen Liu, Hung Hk, Sanyal@hku
Source	Medline; PMC
abstract	Interactions between the host and viruses during the course of their co-evolution have not only shaped cellular function and the immune system, but also the counter measures employed by viruses. Relatively small genomes and high replication rates allow viruses to accumulate mutations and continuously present the host with new challenges. It is therefore, no surprise that they either escape detection or modulate host physiology, often by redirecting normal cellular pathways to their own advantage. Viruses utilize a diverse array of strategies and molecular targets to subvert host cellular processes, while evading detection. These include cell-cycle regulation, major histocompatibility complex-restricted antigen presentation, intracellular protein transport, apoptosis, cytokine-mediated signaling, and humoral immune responses. Moreover, viruses routinely manipulate the host cell cycle to create a favorable environment for replication, largely by deregulating cell cycle checkpoints. This review focuses on our current understanding of the molecular aspects of cell cycle regulation that are often targeted by viruses. Further study of their interactions should provide fundamental insights into cell cycle regulation and improve our ability to exploit these viruses.
has issue date	2018-11-19(xsd:dateTime)
bibo:doi	10.3389/fcimb.2018.00396
bibo:pmid	30510918
has license	cc-by
sha1sum (hex)	6a0f4aac2dfa46df489b653a06df4b5036e452ea
schema:url	https://doi.org/10.3389/fcimb.2018.00396
resource representing a document's title	Breaking Bad: How Viruses Subvert the Cell Cycle
has PubMed Central identifier	PMC6252338
has PubMed identifier	30510918
schema:publication	Front Cell Infect Microbiol
resource representing a document's body	covid:6a0f4aac2dfa46df489b653a06df4b5036e452ea#body_text
is schema:about of	named entity 'high' named entity 'cell cycle' named entity 'Breaking Bad' named entity 'immune system' named entity 'host' named entity 'viruses' named entity 'replication' named entity 'co-evolution' named entity 'antigen presentation' named entity 'physiology' named entity 'replication' named entity 'current' named entity 'viruses' named entity 'apoptosis' named entity 'cell cycle' named entity 'intracellular' named entity 'Subvert' named entity 'mutations' named entity 'Vpr' named entity 'CIP1' named entity 'SLX4' named entity 'cyclin' named entity 'CKI' named entity 'G2 phase' named entity 'nuclear protein' named entity 'WDSV' named entity 'anaphase promoting complex' named entity 'CDK1' named entity 'p17' named entity 'mitosis' named entity 'cell cycle arrest' named entity 'cell cycle control' named entity 'G2/M' named entity 'Epstein-Barr' named entity 'ARV' named entity 'CDK1' named entity 'virally' named entity 'CDK3' named entity 'Walleye' named entity 'HCMV' named entity 'CIP1' named entity 'WAF1' named entity 'E2F' named entity 'CDK1' named entity 'chromatin' named entity 'cyclin' named entity 'KSHV' named entity 'cyclins' named entity 'cell cycle progression' named entity 'Chk2' named entity 'HIV-1' named entity 'cell cycle' named entity 'E1A' named entity 'viral protein' named entity 'E2F' named entity 'protein' named entity 'CDK1' named entity 'kinase' named entity 'cyclin D3' named entity 'gene' named entity 'genetic analysis' named entity 'chromatin' named entity 'p15' named entity 'CDK1' named entity 'Liao' named entity 'HTLV-1' named entity 'ubiquitin ligase' named entity 'DNA-PK' named entity 'cyclin' named entity 'CKI' named entity 'hypophosphorylated' named entity 'N-terminus' named entity 'phosphorylation' named entity 'Cdc25C'

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