About: Vesicular Stomatitis Virus-Vectored Multi-Antigen Tuberculosis Vaccine Limits Bacterial Proliferation in Mice following a Single Intranasal Dose

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About: Vesicular Stomatitis Virus-Vectored Multi-Antigen Tuberculosis Vaccine Limits Bacterial Proliferation in Mice following a Single Intranasal Dose Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Vesicular Stomatitis Virus-Vectored Multi-Antigen Tuberculosis Vaccine Limits Bacterial Proliferation in Mice following a Single Intranasal Dose
Creator	Xiong, Sidong Dong, Chunsheng Zhang, Ming Cicin-Sain, Luka Dhandayuthapani, Subramanian Weinrick, Brian
Source	PMC
abstract	Tuberculosis (TB) remains a serious health problem worldwide, and an urgent need exists to improve or replace the available vaccine, Mycobacterium bovis bacillus Calmette-Guérin (BCG). Most vaccination protocols adapt two or three doses to induce long-term lasting immunity. Our previous study showed that the naked DNA encoding the triple-antigen fusion TFP846 (Rv3615c-Mtb10.4-Rv2660c) induced robust T cellular immune responses accompanying four inoculations against mycobacteria infection. However, a number of compliance issues exist in some areas lacking the appropriate medical infrastructure with multiple administrations. In this study, a novel vesicular stomatitis virus expressing TFP846 (VSV-846) was developed and the immune responses elicited by VSV-846 were evaluated. We observed that intranasal delivery of VSV-846 induced a potent antigen-specific T cell response following a single dose and VSV-846 efficiently controlled bacterial growth to levels ~10-fold lower than that observed in the mock group 6 weeks post-infection in BCG-infected mice. Importantly, mice immunized with VSV-846 provided long-term protection against mycobacteria infection compared with those receiving p846 or BCG immunization. Increased memory T cells were also observed in the spleens of VSV-846-vaccinated mice, which could be a potential mechanism associated with long-term protective immune response. These findings supported the use of VSV as an antigen delivery vector with the potential for TB vaccine development.
has issue date	2017-02-07(xsd:dateTime)
bibo:doi	10.3389/fcimb.2017.00034
bibo:pmid	28224119
has license	cc-by
sha1sum (hex)	6a246d3621609eba5e7fb36c483280aa9cacd166
schema:url	https://doi.org/10.3389/fcimb.2017.00034
resource representing a document's title	Vesicular Stomatitis Virus-Vectored Multi-Antigen Tuberculosis Vaccine Limits Bacterial Proliferation in Mice following a Single Intranasal Dose
has PubMed Central identifier	PMC5293745
has PubMed identifier	28224119
schema:publication	Front Cell Infect Microbiol
resource representing a document's body	covid:6a246d3621609eba5e7fb36c483280aa9cacd166#body_text
is schema:about of	named entity 'BACTERIAL' named entity 'induced' named entity 'developed' named entity 'problem' named entity 'mice' named entity 'vaccine' named entity 'doses' named entity 'accompanying' named entity 'Stomatitis' named entity 'MICE' named entity 'EXIST' named entity 'BACILLUS' named entity 'IMMUNIZED' named entity 'MOCK' named entity 'PREVIOUS' named entity 'AVAILABLE' named entity 'POST' named entity 'TRIPLE' named entity 'IMMUNITY' named entity 'ISSUES' named entity 'TUBERCULOSIS' named entity 'MTB10' named entity 'RV2660C' named entity 'NAKED DNA' named entity 'FOLD' named entity 'AREAS' named entity 'LACKING' named entity 'ENCODING' named entity 'LEVELS' named entity 'T CELL RESPONSE' named entity 'SUPPORTED' named entity 'NUMBER OF' named entity 'DOSES' named entity 'MULTIPLE' named entity 'MYCOBACTERIA' named entity 'FOLLOWING' named entity 'EVALUATED' named entity 'BACTERIAL GROWTH' named entity 'VACCINE DEVELOPMENT' named entity 'FUSION' named entity 'RECEIVING' named entity 'SINGLE' named entity 'INFECTED' named entity 'IMMUNE RESPONSES' named entity 'URGENT' named entity 'VACCINATED' named entity 'BC10' named entity 'NEED' named entity 'ELICITED BY' named entity 'COMPLIANCE' named entity 'COULD BE' named entity 'ASSOCIATED WITH' named entity 'ANTIGEN DELIVERY' named entity 'LOWER' named entity 'ACCOMPANYING' named entity 'MECHANISM' named entity 'SPLEENS' named entity 'APPROPRIATE' named entity 'PROVIDED' named entity 'HEALTH PROBLEM' named entity 'THESE' named entity 'IMMUNE RESPONSE' named entity 'DOSE' named entity 'TUBERCULOSIS VACCINE' named entity 'VECTORED' named entity 'LIMITS' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'NOVEL' named entity 'PROLIFERATION' named entity 'FOLLOWING' named entity 'SINGLE' named entity 'MULTI' named entity 'ANTIGEN' named entity 'LONG-TERM' named entity 'PROTOCOLS' named entity 'VESICULAR STOMATITIS VIRUS'

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