About: Sero-epidemiological study of the rotavirus VP8* protein from different P genotypes in Valencia, Spain

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About: Sero-epidemiological study of the rotavirus VP8* protein from different P genotypes in Valencia, Spain Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Sero-epidemiological study of the rotavirus VP8* protein from different P genotypes in Valencia, Spain
Creator	Buesa, Javier Rodríguez-Díaz, Jesús Gozalbo-Rovira, Roberto Muñoz, Carlos Navarro-Lleó, Noemí Rubio-Del-Campo, Antonio Santiso-Bellón, Cristina Vila-Vicent, Susana
source	PMC
abstract	The aims of the present work were to determine the prevalence and titer of serum antibodies against several rotavirus VP8* proteins from different P genotypes in children and adults in Valencia, Spain; and to determine the role of the secretor status (FUT2(G428A) polymorphism) in the antibody response. The VP8* protein from the P[4], P[6], P[8], P[9], P[11], P[14] and P[25] genotypes were produced in E. coli. These proteins were tested with 88 serum samples from children (n = 41, 3.5 years old in average) and from adults (n = 47, 58 years old in average) by ELISA. A subset of 55 samples were genotyped for the FUT2(G428A) polymorphism and the antibody titers compared. The same subset of samples was also analysed by ELISA using whole rotavirus Wa particles (G1P[8]) as antigen. Ninety-three per cent of the samples were positive for at least one of the VP8* antigens. Differences in the IgG seroprevalence were found between children and adults for the P[4], P[8] and P[11] genotypes. Similarly, significant differences were found between adults and children in their antibody titers against the P[4], P[8], and P[11] VP8* genotypes, having the children higher antibody titers than adults. Interestingly, positive samples against rare genotypes such as P[11] (only in children), P[14] and P[25] were found. While no statistical differences in the antibody titers between secretors and non-secretors were found for any of the tested P genotypes studied, a higher statistic significant prevalence for the P[25] genotype was found in secretors compared to non-secretors. Significant differences in the antibody titers between secretors and non-secretors were found when the whole viral particles from the Wa rotavirus strain (G1P[8]) were used as the antigen.
has issue date	2020-05-08(xsd:dateTime)
bibo:doi	10.1038/s41598-020-64767-x
bibo:pmid	32385405
has license	cc-by
sha1sum (hex)	6a62da853975d18fc1ad84e8b382731ef816b19f
schema:url	https://doi.org/10.1038/s41598-020-64767-x
resource representing a document's title	Sero-epidemiological study of the rotavirus VP8* protein from different P genotypes in Valencia, Spain
has PubMed Central identifier	PMC7210269
has PubMed identifier	32385405
schema:publication	Sci Rep
resource representing a document's body	covid:6a62da853975d18fc1ad84e8b382731ef816b19f#body_text
is schema:about of	named entity 'protein' named entity 'DETERMINE' named entity 'SPAIN' named entity 'PRESENT' named entity 'ADULTS' named entity 'CHILDREN' named entity 'STATUS' named entity 'proteins' named entity 'rotavirus' named entity 'secretor status' named entity 'antibodies' named entity 'antibody response' named entity 'polymorphism' named entity 'Spain' named entity 'VP8' named entity 'VP8' named entity 'rotavirus' named entity 'mucin' named entity 'non-secretors' named entity 'serum samples' named entity 'IgG antibodies' named entity 'antibody' named entity 'epidemiological studies' named entity 'serum samples' named entity 'IgG antibodies' named entity 'blood group antigens' named entity 'G1P' named entity 'vaccines' named entity 'Millipore' named entity 'lysozyme' named entity 'Scientific RepoRtS' named entity 'viral particle' named entity 'fucose' named entity 'antibody' named entity 'genotypes' named entity 'H antigen' named entity 'Rotavac' named entity 'antibody' named entity 'protective antibodies' named entity 'genotypes' named entity 'developing countries' named entity 'genotype' named entity 'blood group' named entity 'statistically significant' named entity 'serum samples' named entity 'standard deviations' named entity 'serum samples' named entity 'PBS' named entity 'Lithuania' named entity 'serum samples' named entity 'rotavirus infections' named entity 'ABO locus' named entity 'antibody' named entity 'genotypes' named entity 'VP8' named entity 'Genotyping' named entity 'antigen' named entity 'genotypes' named entity 'supernatants' named entity 'antibodies' named entity 'non-secretor' named entity 'genotypes' named entity 'polyacrylamide gel' named entity 'informed consent' named entity 'reagent' named entity 'serum samples' named entity 'N-acetylglucosamine' named entity 'ANOVA' named entity 'antibodies' named entity 'DTT' named entity 'genotype' named entity 'GlcNAc' named entity 'subunit vaccine' named entity 'rotavirus'

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