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About:
Diagnostic performance of initial blood urea nitrogen combined with D-Dimer levels for predicting in-hospital mortality in COVID-19 patients
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research paper
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Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Diagnostic performance of initial blood urea nitrogen combined with D-Dimer levels for predicting in-hospital mortality in COVID-19 patients
Creator
Wang, Tao
Li, Jinping
Liu, Qingquan
Liu, Feng
Cheng, Anying
Lv, Yongman
Huang, Luyan
Wang, Yiru
Hu, Liu
Liu, Xiyue
Xu, Ranran
Ye, Dawei
Zhang, Congcong
Zhao, Lingxi
Source
Elsevier; Medline; PMC
abstract
The crude mortality rate in critical pneumonia cases of the new coronavirus disease (COVID-19) has reached 49%. This study aimed to test whether the levels of blood urea nitrogen (BUN) combined D-Dimer were predictors of in-hospital mortality in COVID-19 patients. We analyzed the clinical characteristics of 305 COVID-19 patients and compared them between the survivor and non-survivor groups. A total of 85 (27.9%) patients died, and 220 (72.1%) patients were discharged. Compared with discharged cases, non-survivor cases were older, and their BUN and D-Dimer levels were significantly higher (P<0.0001). LASSON and multivariable COX regression analyses identified BUN and D-Dimer as independent risk factors for poor prognosis. Kaplan-Meier analysis showed that elevated levels of BUN and D-Dimer had increased mortality compared with the other group (log-rank: P<0.0001). The area under the curve for BUN combined D-Dimer was 0.94 (95% CI 0.90–0.97), with a sensitivity of 0.85 and specificity of 91%. Based on BUN and D-Dimer levels on admission, a nomogram model was developed that showed good discrimination, with a C-index of 0.94. Together, initial BUN and D-Dimer levels were associated with mortality in COVID-19 patients. The combination of BUN>4.6 mmol/L and D-Dimer≥0.845 µg/L appears to identify patients of the high risk of in-hospital mortality; therefore, it may prove to be a powerful risk assessment tool for severe COVID-19 patients.
has issue date
2020-07-23
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bibo:doi
10.1016/j.ijantimicag.2020.106110
bibo:pmid
32712332
has license
no-cc
sha1sum (hex)
6a7113066c115a0e665ff3f92c6e63ce07ef840e
schema:url
https://doi.org/10.1016/j.ijantimicag.2020.106110
resource representing a document's title
Diagnostic performance of initial blood urea nitrogen combined with D-Dimer levels for predicting in-hospital mortality in COVID-19 patients
has PubMed Central identifier
PMC7377803
has PubMed identifier
32712332
schema:publication
Int J Antimicrob Agents
resource representing a document's body
covid:6a7113066c115a0e665ff3f92c6e63ce07ef840e#body_text
is
schema:about
of
named entity 'mortality'
named entity 'blood urea nitrogen'
named entity 'levels'
named entity 'Initial'
named entity 'COVID-19'
named entity 'patients'
named entity 'COVID'
named entity 'COVID'
named entity 'D-Dimer'
named entity 'blood urea nitrogen'
named entity 'community-acquired pneumonia'
named entity 'BUN'
named entity 'serum'
named entity 'coronary heart disease'
named entity 'D-Dimer'
named entity 'confidence interval'
named entity 'significant difference'
named entity 'serum albumin levels'
named entity 'COVID-19'
named entity 'plasma'
named entity 'CRP'
named entity 'BUN'
named entity 'BUN'
named entity 'heart failure'
named entity 'nausea'
named entity 'risk factors'
named entity 'COVID-19'
named entity 'antibiotics'
named entity 'BUN'
named entity 'non-normally distributed'
named entity 'Receiver operating characteristic'
named entity 'blood urea nitrogen'
named entity 'procalcitonin'
named entity 'D-Dimer'
named entity 'clinical symptoms'
named entity 'antiviral'
named entity 'regression analysis'
named entity 'protein metabolism'
named entity 'complete blood count'
named entity 'SPSS'
named entity 'chi-square test'
named entity 'eGFR'
named entity 'confounders'
named entity 'immunoglobulin'
named entity 'renal function'
named entity 'COVID'
named entity 'CAP'
named entity 'BUN'
named entity 'rate of mortality'
named entity 'SARS-CoV-2 virus'
named entity 'lactate dehydrogenase'
named entity 'C-reactive protein'
named entity 'regression analysis'
named entity 'BUN'
named entity 'CRP'
named entity 'P.R. China'
named entity 'prognostic factor'
named entity 'prognosis'
named entity 'BUN'
named entity 'D-Dimer'
named entity 'diabetes'
named entity 'eGFR'
named entity 'BUN'
named entity 'ROC'
named entity 'pneumonia'
named entity 'Tongji Hospital'
named entity 'chronic obstructive pulmonary disease'
named entity 'subgroup analysis'
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