About: The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy
Creator	Casas, Inmaculada Calvo, Cristina Méndez-Echevarría, Ana Pozo, Francisco Del Rosal, Teresa García-García, Luz Madrid, Spain María, \| Paz, La Benavides-Nieto, Marta De La Serna, Olga Lopez-Granados, \| Rodriguez-Pena, Rebeca
source	Medline; PMC
abstract	BACKGROUND: The role of viruses in children with respiratory tract infections and humoral immunodeficiencies has hardly been studied. We have evaluated these infections in children with humoral immunodeficiencies who required immunoglobulin replacement therapy, considering their relationship with symptoms, lung function, bacterial co‐infection, and outcomes. METHODS: We conducted a prospective case‐control study during a 1‐year period, including children with humoral immunodeficiencies receiving immunoglobulin replacement therapy. For each patient, at least one healthy family member was included. Respiratory samples for viral detection were taken every 1‐3 months, and in case of respiratory tract infections. Symptoms questionnaires were filled biweekly. Spirometry and sputum culture were performed in every episode. RESULTS: Sixty‐six episodes were analyzed in 14 patients (median age 12 years; IQR 7‐17), identifying 18 respiratory viruses (27.3%), being rhinovirus the most frequently isolated one (12/18; 66%). Positive viral episodes were associated with clinical symptoms (89% vs 43%), more frequent antibiotic treatment (44% vs 15%) or hospital admission (22% vs 0%) than negative ones. Patients with positive viral detection showed impaired lung function, with lower FEV1 and FVC values. CONCLUSIONS: In our experience, viral respiratory tract infections can cause significant respiratory symptoms and impaired lung function, in children with HID, despite immunoglobulin replacement therapy. These patients could benefit from the monitoring of viral infections, as these may be a gateway for ongoing lung damage.
has issue date	2018-12-21(xsd:dateTime)
bibo:doi	10.1002/ppul.24214
bibo:pmid	30575324
has license	no-cc
sha1sum (hex)	6a7877fcc08e505d097187cb928a649d8ae5d994
schema:url	https://doi.org/10.1002/ppul.24214
resource representing a document's title	The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy
has PubMed Central identifier	PMC7167964
has PubMed identifier	30575324
schema:publication	Pediatr Pulmonol
resource representing a document's body	covid:6a7877fcc08e505d097187cb928a649d8ae5d994#body_text
is schema:about of	named entity 'humoral' named entity 'viruses' named entity 'BACKGROUND' named entity 'RESPIRATORY TRACT INFECTIONS' covid:arg/6a7877fcc08e505d097187cb928a649d8ae5d994 named entity 'therapy' named entity 'lung function' named entity 'immunodeficiencies' named entity 'spirometry' named entity 'T-cell' named entity 'bacterial infections' named entity 'influenza viruses' named entity 'primary immunodeficiency' named entity 'nasopharyngeal' named entity 'human bocavirus' named entity 'interstitial lung disease' named entity 'GLILD' named entity 'PWM' named entity 'antibiotic treatment' named entity 'B-cell' named entity 'viruses' named entity 'X-linked agammaglobulinemia' named entity 'IgG' named entity 'Immunoglobulin' named entity 'Lung' named entity 'enteroviruses' named entity 'Human herpesvirus 8' named entity 'antibody deficiency' named entity 'pathogens' named entity 'immunodeficiencies' named entity 'Madrid' named entity 'Spain' named entity 'cough' named entity 'nasopharyngeal swab' named entity 'lung function' named entity 'respiratory infections' named entity 'lung complications' named entity 'respiratory distress' named entity 'pathogens' named entity 'pulmonary complications' named entity 'respiratory symptoms' named entity 'humoral' named entity 'combined immunodeficiency' named entity 'viruses' named entity 'immunosuppressive' named entity 'immunoglobulin' named entity 'respiratory infections' named entity 'outpatient' named entity 'C-reactive protein' named entity 'Influenza' named entity 'bronchiectasis' named entity 'SCID' named entity 'immune dysregulation' named entity 'sequelae' named entity 'CVID' named entity 'B-cell' named entity 'lymphopenia' named entity 'human metapneumovirus' named entity 'viral infection' named entity 'chronic lung disease' named entity 'pneumonia' named entity 'OC43' named entity 'sputum' named entity 'common variable immunodeficiency' named entity 'SCID' named entity 'sputum' named entity 'sputum culture' named entity 'antibody deficiency' named entity 'aspirates'

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