About: Proteomic analysis reveals platelet factor 4 and beta‐thromboglobulin as prognostic markers in severe acute respiratory syndrome

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About: Proteomic analysis reveals platelet factor 4 and beta‐thromboglobulin as prognostic markers in severe acute respiratory syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Proteomic analysis reveals platelet factor 4 and beta‐thromboglobulin as prognostic markers in severe acute respiratory syndrome
Creator	Lee, Nelson Sung, Joseph Chan, K Chim, Stephen Chiu, Rossa Dennis Lo, Y Ka, Li Ngai, Sai Pang, Ronald Poon, Terence Tong, Yu-Kwan Insti, Shing
source	Medline; PMC
abstract	Previously, we reported that proteomic fingerprints were present in sera of patients with severe acute respiratory syndrome (SARS), and could separate patients into subgroups with different prognoses. In the present study, we examined the prognostic values of the SARS‐associated proteomic features by biostatistical analysis, and deciphered the identities of those with prognostic values. Data of 20 SARS‐associated serum proteomic features and ten serological variables from 38 SARS adult patients before treatment were subjected to multivariate logistic regression. Proteomic features of m/z 6634, m/z 7769, m/z 8635, and m/z 8865 were identified as independent prognostic markers. After purification by cation‐exchange chromatography and gel electrophoresis, proteomic features of m/z 7769 and m/z 8865 were found to be platelet factor 4 (PF4) and beta‐thromboglobulin (beta‐TG) by tandem mass spectrometry, respectively. The associations of decreased serum PF4 and increased serum beta‐TG levels with poor prognosis were confirmed by Western blot. Previous studies suggest that PF4 and beta‐TG are involved in the pathogenesis of acute respiratory distress syndrome (ARDS) in a negative and positive way, respectively. Our results suggest that PF4 and beta‐TG may also play similar roles in the development of ARDS in SARS patients.
has issue date	2012-06-28(xsd:dateTime)
bibo:doi	10.1002/elps.201200002
bibo:pmid	22740477
has license	no-cc
sha1sum (hex)	6a8a8560af6766a4f9536aec677b611522ebe589
schema:url	https://doi.org/10.1002/elps.201200002
resource representing a document's title	Proteomic analysis reveals platelet factor 4 and beta‐thromboglobulin as prognostic markers in severe acute respiratory syndrome
has PubMed Central identifier	PMC7163558
has PubMed identifier	22740477
schema:publication	Electrophoresis
resource representing a document's body	covid:6a8a8560af6766a4f9536aec677b611522ebe589#body_text
is schema:about of	named entity 'serum' named entity 'ROLES' named entity 'PROGNOSES' named entity 'WESTERN BLOT' named entity 'TANDEM MASS SPECTROMETRY' named entity 'SUGGEST' named entity 'NEGATIVE' named entity 'IDENTIFIED' named entity 'REPORTED' named entity 'PLATELET FACTOR 4 ' named entity 'SUBGROUPS' named entity 'PRESENT' named entity 'INCREASED' named entity 'POSITIVE' named entity 'proteomic' named entity 'identities' named entity 'prognostic' named entity 'serum' named entity 'study' named entity 'acute respiratory distress syndrome (ARDS)' named entity 'Data' named entity 'PF4' named entity 'prognostic' named entity 'prognoses' named entity 'variables' named entity 'prognosis' named entity 'platelet factor 4' named entity 'gel electrophoresis' named entity 'm/z' named entity 'Western blot' named entity 'm/z' named entity 'PF4' named entity 'm/z' named entity 'serological' named entity 'protein' named entity 'PF4' named entity 'peptide' named entity 'diffuse alveolar damage' named entity 'SARS' named entity 'm/z' named entity 'polyacrylamide gels' named entity 'pathogenesis' named entity 'SARS coronavirus' named entity 'artificial heart valves' named entity 'proteomic' named entity 'T-cell' named entity 'fever' named entity 'serum' named entity 'PF4' named entity 'proteomic' named entity 'peptide' named entity 'lymphocyte count' named entity 'neutrophil' named entity 'chemokines' named entity 'neutrophil' named entity 'chemokines' named entity 'serology test' named entity 'LDH' named entity 'Bio-Rad' named entity 'antibody' named entity 'prognosis' named entity 'plasma' named entity 'steroids' named entity 'SELDI' named entity 'PF4' named entity 'cyano' named entity 'p-values' named entity 'logistic regression' named entity 'serum samples' named entity 'proteomic'

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