About: Epidemiological and clinical characteristics of COVID-19 patients in Hengyang, Hunan Province, China

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Epidemiological and clinical characteristics of COVID-19 patients in Hengyang, Hunan Province, China
Creator	Liu, Jing Tang, Jian Yang, Xia Hu, Yang Yan, Bo Tang, Xiao-Qing Jiang, Bo Liu, Qiong Huang, Jia Tang, J Cy, Dou Dai, Rong-Juan Deng, Li-Pu Dou, Cheng-Yun Fu, Nian Hy, Yao Jc, Zhou Lin, Hai-Lian Lp, Deng Peng, Jin-Ling Rj, Dai Tian, Ya-Ying Xie, Xia Yang, Xue-Feng Yao, Hong-Yi Yy, Tian Zf, Zhong Zhang, Xiao-Yan Zhong, Zhe-Feng Zhou, Jie-Can
source	Medline; PMC
abstract	BACKGROUND: In December 2019, an ongoing outbreak of coronavirus disease 2019 (COVID-19) was first identified in Wuhan, China. The characteristics of COVID-19 patients treated in local hospitals in Wuhan are not fully representative of patients outside Wuhan. Therefore, it is highly essential to analyze the epidemiological and clinical characteristics of COVID-19 in areas outside Wuhan or Hubei Province. To date, a limited number of studies have concentrated on the epidemiological and clinical characteristics of COVID-19 patients with different genders, clinical classification, and with or without basic diseases. AIM: To study the epidemiological and clinical characteristics of COVID-19 patients in Hengyang (China) and provide a reliable reference for the prevention and control of COVID-19. METHODS: From January 16 to March 2, 2020, a total of 48 confirmed cases of COVID-19 were reported in Hengyang, and those cases were included in this study. The diagnostic criteria, clinical classification, and discharge standard related to COVID-19 were in line with the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7) released by National Health Commission and National Administration of Traditional Chinese Medicine. The presence of SARS-CoV-2 in pharyngeal swab specimens was detected by quantitative reverse transcription polymerase chain reaction. All the data were imported into the excel worksheet and statistically analyzed by using SPSS 25.0 software. RESULTS: A total of 48 cases of COVID-19 were collected, of which 1 was mild, 38 were moderate, and 9 were severe. It was unveiled that there were 31 (64.6%) male patients and 17 (35.4%) female patients, with a female-to-male ratio of 1.82:1. The range of age of patients with COVID-19 was dominantly 30-49 years old [25 (52.1%) of 48], followed by those aged over 60 years old [11 (22.9%)]. Besides, 29.2% (14 of 48) of patients had basic diseases, and 57.2% (8 of 14) of patients with basic diseases were aged over 60 years old. The occupations of 48 COVID-19 patients were mainly farmers working in agricultural production [15 (31.5%) of 48], rural migrant workers from Hengyang to Wuhan [15 (31.5%)], and service workers operating in the service sector [8 (16.7%)]. The mean latent period was 6.86 ± 3.57 d, and the median was 7 [interquartile range (IQR): 4-9] d. The mean time from onset of symptoms to the first physician visit was 3.38 ± 2.98 (95%CI: 2.58-9.18) d, with a median of 2 (IQR: 1-5) d, and the mean time from hospital admission to confirmed diagnosis was 2.29 ± 2.11 (95%CI: 1.18-6.42) d, with a median of 2 (IQR: 1-3) d. The main symptoms were fever [43 (89.6%) of 48], cough and expectoration [41 (85.4%)], fatigue [22 (45.8%)], and chills [22 (45.8%)]. Other symptoms included poor appetite [13 (27.1%)], sore throat [9 (18.8%)], dyspnea [9 (18.8%)], diarrhea [7 (14.6%)], dizziness [5 (10.4%)], headache [5 (10.4%)], muscle pain [5 (10.4%)], nausea and vomiting [4 (8.3%)], hemoptysis [4 (8.3%)], and runny nose [1 (2.1%)]. The numbers of peripheral blood leukocytes, lymphocytes, and eosinophils were significantly reduced in the majority of the patients. The levels of C-reactive protein, fibrinogen, blood glucose, lactate dehydrogenase, D-dimer, alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (γ-GT), myoglobin (MB), and creatine kinase (CK) were increased in 64.6%, 44.7%, 43.2%, 37.0%, 29.5%, 22.9%,20.8%, 21.6%, 13.6%, and 12.8% of patients, respectively. The incidence of ALT elevation in male patients was remarkably higher than that in females (P < 0.01), while the incidences of AST, CK, and blood glucose elevations in severe patients were remarkably higher than those in moderate patients (P < 0.05, respectively). Except for the mild patients, chest computed tomography showed characteristic pulmonary lesions. All the patients received antiviral drugs, 38 (79.2%) accepted traditional Chinese medicine, and 2 (4.2%) received treatment of human umbilical-cord mesenchymal stem cells. On March 2, 2020, 48 patients with COVID-19 were all cured and discharged. CONCLUSION: Based on our results, patients with COVID-19 often have multiple organ dysfunction or damage. The incidences of ALT elevation in males, and AST, CK, and blood glucose elevations in severe patients are remarkably higher.
has issue date	2020-06-26(xsd:dateTime)
bibo:doi	10.12998/wjcc.v8.i12.2554
bibo:pmid	32607332
has license	cc-by-nc
sha1sum (hex)	6aa1be5ee975bda4ea0fbfbda9c6c033dcf89b15
schema:url	https://doi.org/10.12998/wjcc.v8.i12.2554
resource representing a document's title	Epidemiological and clinical characteristics of COVID-19 patients in Hengyang, Hunan Province, China
has PubMed Central identifier	PMC7322431
has PubMed identifier	32607332
schema:publication	World J Clin Cases
resource representing a document's body	covid:6aa1be5ee975bda4ea0fbfbda9c6c033dcf89b15#body_text
is schema:about of	named entity 'COVID-19' named entity 'Hunan Province' named entity 'Epidemiological' named entity 'clinical characteristics' named entity 'COVID-19' named entity 'Hengyang' named entity 'International Committee on Taxonomy of Viruses' named entity 'asymptomatic' named entity 'antigen' named entity 'hepatitis' named entity 'Hengyang' named entity 'enzyme' named entity 'COVID' named entity 'wildlife market' named entity 'antibody' named entity 'eosinophils' named entity 'Pneumonia' named entity 'traditional Chinese medicine' named entity 'Hengyang' named entity 'hypertension' named entity 'infection control' named entity 'COVID' named entity 'AST' named entity 'diabetes' named entity 'Hengyang' named entity 'epidemic' named entity 'Coronavirus' named entity 'asymptomatic patients' named entity 'RNA' named entity 'COVID' named entity 'Pneumonia' named entity 'COVID' named entity 'COVID' named entity 'COVID' named entity 'China' named entity 'COVID' named entity 'coronavirus' named entity 'lymphocytes' named entity 'hypertension' named entity 'SARS-CoV-2' named entity 'fibrinogen' named entity 'latent period' named entity 'COVID' named entity 'COVID-19' named entity 'gout' named entity 'eosinophils' named entity 'PCR' named entity 'infection' named entity 'mesenchymal stem cells' named entity 'Hengyang' named entity 'fever' named entity 'SARS-CoV-2'

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