About: Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications
Creator	Drucker, Daniel
Source	Medline; PMC
abstract	Individuals with diabetes are at increased risk for bacterial, mycotic, parasitic and viral infections. The severe acute respiratory syndrome (SARS)-CoV2 (also referred to as COVID-19) coronavirus pandemic highlights the importance of understanding shared disease pathophysiology potentially informing therapeutic choices in individuals with Type 2 diabetes (T2D). Two coronavirus receptor proteins, Angiotensin Converting Enzyme 2 (ACE2) and Dipeptidyl Peptidase-4 (DPP4) are also established transducers of metabolic signals and pathways regulating inflammation, renal and cardiovascular physiology, and glucose homeostasis. Moreover, glucose-lowering agents such as the DPP4 inhibitors, widely used in subjects with T2D, are known to modify the biological activities of multiple immunomodulatory substrates. Here we review the basic and clinical science spanning the intersections of diabetes, coronavirus infections, ACE2, and DPP4 biology, highlighting clinical relevance and evolving areas of uncertainty underlying the pathophysiology and treatment of T2D in the context of coronavirus infection
has issue date	2020-04-15(xsd:dateTime)
bibo:doi	10.1210/endrev/bnaa011
bibo:pmid	32294179
has license	no-cc
sha1sum (hex)	6ad3490bc320df51532e92edb220c2b6b3657048
schema:url	https://doi.org/10.1210/endrev/bnaa011
resource representing a document's title	Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications
has PubMed Central identifier	PMC7184382
has PubMed identifier	32294179
schema:publication	Endocr Rev
resource representing a document's body	covid:6ad3490bc320df51532e92edb220c2b6b3657048#body_text
is schema:about of	named entity 'Dipeptidyl Peptidase-4' named entity 'Angiotensin Converting Enzyme 2' named entity 'DPP4' named entity 'immunomodulatory' named entity 'DPP4' named entity 'glucose homeostasis' named entity 'ACE2' named entity 'parasitic' named entity 'COVID' named entity 'inflammation' named entity 'ACE2' named entity 'coronavirus infection' named entity 'type 2 diabetes' named entity 'metalloproteinase' named entity 'diabetes and pregnancy' named entity 'Insulin' named entity 'SARS-CoV-2' named entity 'insulin' named entity 'cardiometabolic' named entity 'amino acid' named entity 'continuous glucose monitoring' named entity 'SARS-CoV-2' named entity 'plasma levels' named entity 'ICUs' named entity 'ACE2' named entity 'study endpoint' named entity 'ACE2' named entity 'Angiotensin' named entity 'spike protein' named entity 'bradykinin' named entity 'immune responses' named entity 'T2D' named entity 'non-selective' named entity 'diabetes' named entity 'MERS-CoV' named entity 'CD8' named entity 'Angiotensin II' named entity 'virus' named entity 'Ang II' named entity 'SARS-CoV-2' named entity 'diabetes' named entity 'TMPRSS2' named entity 'BMI' named entity 'transgenic mice' named entity 'angiotensin' named entity 'respiratory infection' named entity 'HIV infections' named entity 'lung' named entity 'amylase' named entity 'DPP4' named entity 'chemokines' named entity 'coronavirus' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'human subjects' named entity 'Sulfonylureas' named entity 'Pancreatic injury' named entity 'angiotensin II' named entity 'mesothelium' named entity 'lung tissue' named entity 'anti-M' named entity 'systemic sepsis' named entity 'pancreas' named entity 'DPP4' named entity 'mice' named entity 'diabetes' named entity 'critical illness' named entity 'inflammation' named entity 'spike protein' named entity 'DPP4' named entity 'DPP4' named entity 'diabetes' named entity 'epithelial tissues' named entity 'amino acid' named entity 'immunomodulatory' named entity 'DPP4' named entity 'MERS-CoV' named entity 'DPP4' named entity 'amino acid sequence' named entity 'HIV+' named entity 'receptor'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software