About: Experimental infection of Cynomolgus Macaques with highly pathogenic H5N1 influenza virus through the aerosol route

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About: Experimental infection of Cynomolgus Macaques with highly pathogenic H5N1 influenza virus through the aerosol route Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Experimental infection of Cynomolgus Macaques with highly pathogenic H5N1 influenza virus through the aerosol route
Creator	Hasegawa, Hideki Kawaoka, Yoshihiro Nakajima, Noriko Watanabe, Tokiko Takahashi, Kenta Fukuyama, Satoshi Ito, Mutsumi Iwatsuki-Horimoto, Kiyoko Kiso, Maki Da, Tiago Lopes, Silva
Source	PMC
abstract	Several animal models are used to study influenza viruses. Intranasal inoculation of animals with a liquid inoculum is one of the main methods used to experimentally infect animals with influenza virus; however, this method does not reflect the natural infection with influenza virus by contact or aerosol route. Aerosol inhalation methods have been established with several influenza viruses for mouse and ferret models, but few studies have evaluated inoculation routes in a nonhuman primates (NHP) model. Here, we performed the experimental infection of NHPs with a highly pathogenic H5N1 influenza virus via the aerosol route and demonstrated that aerosol infection had no effect on clinical outcome, but caused broader infection throughout all of the lobes of the lung compared with a non-aerosolized approach. Aerosol infection therefore represents an option for inoculation of NHPs in future studies.
has issue date	2018-03-19(xsd:dateTime)
bibo:doi	10.1038/s41598-018-23022-0
bibo:pmid	29556081
has license	cc-by
sha1sum (hex)	6ae480b7554d3210fa26f2410a6ed06ade025eec
schema:url	https://doi.org/10.1038/s41598-018-23022-0
resource representing a document's title	Experimental infection of Cynomolgus Macaques with highly pathogenic H5N1 influenza virus through the aerosol route
has PubMed Central identifier	PMC5859186
has PubMed identifier	29556081
schema:publication	Sci Rep
resource representing a document's body	covid:6ae480b7554d3210fa26f2410a6ed06ade025eec#body_text
is schema:about of	named entity 'PUBLISHED' named entity 'PATHOGENIC' named entity 'EXPERIMENTAL INFECTION' named entity 'H5N1 INFLUENZA' named entity 'NATURE' named entity 'OPEN' named entity 'SCIENTIFIC' named entity 'INFLUENZA VIRUS' named entity 'AEROSOL' named entity 'ROUTE' named entity 'MACAQUES' named entity 'REPORTS' named entity 'CYNOMOLGUS' named entity 'HIGHLY' named entity 'COM' named entity 'WWW' named entity 'ScIentIfIc REpoRTS' named entity 'Cynomolgus Macaques' named entity 'influenza virus' named entity 'antigen' named entity 'intratracheal' named entity 'Animal tissues' named entity 'virus' named entity 'ultrasonic' named entity 'biosafety level 3' named entity 'virus' named entity 'pathogenicity' named entity 'antigen' named entity 'inoculation' named entity 'intranasal' named entity 'tissue samples' named entity 'virus' named entity 'avian influenza virus' named entity 'viruses' named entity 'titration' named entity 'pathogenicity' named entity 'influenza virus' named entity 'intranasal' named entity 'virus' named entity 'trachea' named entity 'virus' named entity 'viral antigens' named entity 'Pathologic' named entity 'aerosol' named entity 'nebulizer' named entity 'alveolar spaces' named entity 'aerosol' named entity 'decontamination' named entity 'inoculation' named entity 'ketamine' named entity 'H5N1' named entity 'histopathologic' named entity 'infection' named entity 'H5N1' named entity 'aerosol' named entity 'adenine' named entity 'Kyoto University' named entity 'intratracheal' named entity 'aerosol' named entity 'virus' named entity 'murine' named entity 'lower respiratory tract' named entity 'Pathologic' named entity 'infection' named entity 'lung' named entity 'Histopathologic' named entity 'viruses' named entity 'Cambodia' named entity 'Animal Experimentation' named entity 'nuclei' named entity 'virus'

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