About: Two pathways of costimulation through CD28

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Two pathways of costimulation through CD28
Creator	Sanchez-Lockhart, Mariano Miller, J Wang, A Wang, Á Yang, Á Ae, Christina Ae, Graf Ae, Jim Ae, Katherine Ae, Takeshi Baker, Á Barbara, Yang Beth, A Cook, Kevin Cook, Á Graf, Á Sanchez-Lockhart, Á Sharp, Ae Sharp, Á Yoshida, Yoshida, Á
Source	PMC
abstract	CD28 is recognized as the primary costimulatory molecule involved in the activation of naïve T cells. However, the biochemical signaling pathways that are activated by CD28 and how these pathways are integrated with TCR signaling are still not understood. We have recently shown that there are at least two independent activation pathways induced by CD28 costimulation. One is integrated with TCR signaling in the context of the immunological synapse and is mediated through transcriptional enhancement and the second is mediated through the induction of mRNA stability. Here, we review the immunological consequences and biochemical mechanisms associated with CD28 costimulation and discuss the major questions that need to be resolved to understand the molecular mechanisms that transduce CD28 costimulation.
has issue date	2009-02-13(xsd:dateTime)
bibo:doi	10.1007/s12026-009-8097-6
bibo:pmid	19214786
has license	no-cc
sha1sum (hex)	6aead323d4d66b2a670748159a592f43a74c9ec3
schema:url	https://doi.org/10.1007/s12026-009-8097-6
resource representing a document's title	Two pathways of costimulation through CD28
has PubMed Central identifier	PMC7091045
has PubMed identifier	19214786
schema:publication	Immunol Res
resource representing a document's body	covid:6aead323d4d66b2a670748159a592f43a74c9ec3#body_text
is schema:about of	named entity 'CD28' named entity 'MECHANISMS' named entity 'REVIEW' named entity 'INDUCED' named entity 'DISCUSS' named entity 'CONSEQUENCES' named entity 'INVOLVED' named entity 'immunological synapse' named entity 'costimulation' named entity 'signaling' named entity 'Two' named entity 'CD28' named entity 'costimulation' named entity 'transduce' named entity 'CD28' named entity 'biochemical' named entity 'immunological synapse' named entity 'transcriptional' named entity 'costimulation' named entity 'costimulation' named entity 'CD45' named entity 'nucleic acid' named entity 'Akt' named entity 'Bcl-XL' named entity 'Lck' named entity 'transcription' named entity 'amino acid' named entity 'CD28' named entity 'ligands' named entity 'SH3' named entity 'Bcl-XL' named entity 'CD4' named entity 'cytosolic' named entity 'CD28' named entity 'mRNA' named entity 'Lck' named entity 'humoral responses' named entity 'lipid rafts' named entity 'PI3K' named entity 'Mutation' named entity 'cytosolic' named entity 'phosphatase' named entity 'IL-2' named entity 'critical role' named entity 'immunological synapse' named entity 'CD28' named entity 'cell cycle regulator' named entity 'mutation' named entity 'pathogen' named entity 'CD28' named entity 'cell migration' named entity 'secretion' named entity 'SH2' named entity 'SH3' named entity 'separate site' named entity 'antigen' named entity 'Jurkat cells' named entity 'immunological synapse' named entity 'smooth muscle cells' named entity 'YB-1' named entity 'costimulation'

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