About: Recombinant infectious bronchitis virus (IBV) H120 vaccine strain expressing the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) protects chickens against IBV and NDV challenge

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About: Recombinant infectious bronchitis virus (IBV) H120 vaccine strain expressing the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) protects chickens against IBV and NDV challenge Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Recombinant infectious bronchitis virus (IBV) H120 vaccine strain expressing the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) protects chickens against IBV and NDV challenge
Creator	Li, Jianan Wang, Hongning Yang, Xin Zeng, Fanya Gao, Wenqian Li, • Zhou, Yingshun Zhou, • Gaosheng, •
Source	Medline; PMC
abstract	Infectious bronchitis (IB) and Newcastle disease (ND) are common viral diseases of chickens, which are caused by infectious bronchitis virus (IBV) and Newcastle disease virus (NDV), respectively. Vaccination with live attenuated strains of IBV-H120 and NDV-LaSota are important for the control of IB and ND. However, conventional live attenuated vaccines are expensive and result in the inability to differentiate between infected and vaccinated chickens. Therefore, there is an urgent need to develop new efficacious vaccines. In this study, using a previously established reverse genetics system, we generated a recombinant IBV virus based on the IBV H120 vaccine strain expressing the haemagglutinin-neuraminidase (HN) protein of NDV. The recombinant virus, R-H120-HN/5a, exhibited growth dynamics, pathogenicity and viral titers that were similar to those of the parental IBV H120, but it had acquired hemagglutination activity from NDV. Vaccination of SPF chickens with the R-H120-HN/5a virus induced a humoral response at a level comparable to that of the LaSota/H120 commercial bivalent vaccine and provided significant protection against challenge with virulent IBV and NDV. In summary, the results of this study indicate that the IBV H120 strain could serve as an effective tool for designing vaccines against IB and other infectious diseases, and the generation of IBV R-H120-HN/5a provides a solid foundation for the development of an effective bivalent vaccine against IBV and NDV.
has issue date	2016-02-12(xsd:dateTime)
bibo:doi	10.1007/s00705-016-2764-4
bibo:pmid	26873815
has license	no-cc
sha1sum (hex)	6b1b1794fd25ebbbe0839b59ed72f3cbe3e2188b
schema:url	https://doi.org/10.1007/s00705-016-2764-4
resource representing a document's title	Recombinant infectious bronchitis virus (IBV) H120 vaccine strain expressing the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) protects chickens against IBV and NDV challenge
has PubMed Central identifier	PMC7087005
has PubMed identifier	26873815
schema:publication	Arch Virol
resource representing a document's body	covid:6b1b1794fd25ebbbe0839b59ed72f3cbe3e2188b#body_text
is schema:about of	named entity 'vaccines' named entity 'chickens' named entity 'hemagglutinin-neuraminidase' named entity 'RECOMBINANT' named entity 'CHICKENS' named entity 'CHALLENGE' named entity 'CHALLENGE' named entity 'CHICKENS' named entity 'INFECTED' named entity 'SERVE' named entity 'PARENTAL' named entity 'SIGNIFICANT' named entity 'PROTECTION' named entity 'VACCINE STRAIN' named entity 'GROWTH' named entity 'SYSTEM' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'USING' named entity 'BUT' named entity 'RECOMBINANT VIRUS' named entity 'STRAINS' named entity 'HEMAGGLUTINATION' named entity 'CONTROL' covid:arg/6b1b1794fd25ebbbe0839b59ed72f3cbe3e2188b named entity 'STRAIN' named entity 'VIRAL DISEASES' named entity 'STUDY' named entity 'CONVENTIONAL' named entity 'ACTIVITY' named entity 'REVERSE GENETICS' named entity 'SPF' named entity 'LIVE' named entity 'PATHOGENICITY' named entity 'CAUSED BY' named entity 'NEED' named entity 'GENERATION' named entity 'LEVEL' named entity 'DIFFERENTIATE' named entity 'INFECTIOUS BRONCHITIS' named entity 'NEWCASTLE DISEASE' named entity 'HEMAGGLUTININ-NEURAMINIDASE' named entity 'PROTEIN ' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'VIRULENT' named entity 'RECOMBINANT' named entity 'SIMILAR' named entity 'BASED' named entity 'ATTENUATED VACCINES' named entity 'NEWCASTLE DISEASE VIRUS' named entity 'PROVIDED' named entity 'HUMORAL RESPONSE' named entity 'VACCINATION' named entity 'ATTENUATED' named entity 'DYNAMICS' named entity 'COMMERCIAL' named entity 'HAEMAGGLUTININ' named entity 'VACCINE STRAIN' named entity 'NEWCASTLE DISEASE VIRUS' named entity 'IMPORTANT' named entity 'VACCINES' named entity 'TOOL' named entity 'INDUCED' named entity 'DEVELOPMENT' named entity 'FOUNDATION' named entity 'SUMMARY' named entity 'ESTABLISHED' named entity 'GENERATED' named entity 'EFFECTIVE' named entity 'COMMON' named entity 'PROVIDES' named entity 'ACQUIRED' named entity 'RESULT' named entity 'OTHER INFECTIOUS DISEASES'

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