About: Immunization with West Nile virus envelope domain III protects mice against lethal infection with homologous and heterologous virus

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About: Immunization with West Nile virus envelope domain III protects mice against lethal infection with homologous and heterologous virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunization with West Nile virus envelope domain III protects mice against lethal infection with homologous and heterologous virus
Creator	Osterhaus, Albert Rimmelzwaan, Guus Koraka, Penelopie Martina, Byron Van Amerongen, Geert Van Den Doel, Petra
Source	Elsevier; Medline; PMC
abstract	Summary The Japanese encephalitis virus (JEV) serocomplex-group consists of mosquito-borne flaviviruses, which include West Nile virus (WNV) and JEV, and both may cause severe encephalitis in humans. WNV has spread rapidly across the United States since its introduction in 1999 and its geographical distribution within the western hemisphere is expected to further expand, whereas, JEV is the most common cause of viral encephalitis in Southeast Asia, China and India. Currently, there is no registered human vaccine or specific therapy to prevent or treat WNV infection. Here we describe the efficacy of recombinant domain III (DIII) of WNV glycoprotein E in a mouse model. It induces high neutralizing antibody titers, as well as, protection against lethal WNV infection in C57BL/6 mice. This vaccine preparation also afforded partial protection against lethal JEV infection.
has issue date	2008-01-10(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2007.10.055
bibo:pmid	18069096
has license	els-covid
sha1sum (hex)	6b1d17b31523708ac03b323ba761260ecb7cacb1
schema:url	https://doi.org/10.1016/j.vaccine.2007.10.055
resource representing a document's title	Immunization with West Nile virus envelope domain III protects mice against lethal infection with homologous and heterologous virus
has PubMed Central identifier	PMC7127062
has PubMed identifier	18069096
schema:publication	Vaccine
resource representing a document's body	covid:6b1d17b31523708ac03b323ba761260ecb7cacb1#body_text
is schema:about of	named entity 'IMMUNIZATION' named entity 'lethal' named entity 'heterologous' named entity 'DOMAIN' named entity 'WEST NILE VIRUS' named entity 'VIRUS' named entity 'HETEROLOGOUS' named entity 'HOMOLOGOUS' named entity 'LETHAL INFECTION' named entity 'VIRUS ENVELOPE' named entity 'III' named entity 'MICE' named entity 'III' named entity 'Immunization' named entity 'heterologous' named entity 'West Nile virus' named entity 'dengue virus' named entity 'China' named entity '1:25' named entity 'Vero E6' named entity 'WNV' named entity 'affinity chromatography' named entity 'vaccine' named entity 'JEV' named entity 'C57BL/6' named entity 'PBS' named entity 'brain tissues' named entity 'mice' named entity 'JEV' named entity 'WNV' named entity 'mice' named entity 'mice' named entity 'monoclonal antibody' named entity 'vaccine' named entity 'Glostrup' named entity 'epitopes' named entity 'IgG' named entity 'vaccine' named entity 'prokaryotic cells' named entity 'PBS' named entity 'vaccine' named entity 'WNV' named entity 'mice' named entity 'WNV' named entity 'SARS coronavirus' named entity 'vaccine' named entity 'Zwijndrecht' named entity 'survival rates' named entity 'biosafety' named entity 'vaccine' named entity 'virus' named entity 'weight loss' named entity 'protein' named entity 'JEV' named entity 'adjuvanted' named entity 'mice' named entity 'WNV' named entity 'immunogenicity' named entity 'WNV' named entity 'viral encephalitis' named entity 'cell culture' named entity 'BALB/c' named entity 'Vaccinated' named entity 'WNV' named entity 'JEV' named entity 'neutralizing antibodies' named entity 'JEV' named entity 'WNV' named entity 'WNV' named entity 'virulence' named entity 'w/v' named entity 'China' named entity 'neutralizing antibodies' named entity 'Netherlands' named entity 'nucleotides' named entity '450 nm'

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