About: IFITM3 and Susceptibility to Respiratory Viral Infections in the Community

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	IFITM3 and Susceptibility to Respiratory Viral Infections in the Community
Creator	Goossens, Herman Ieven, Margareta Little, Paul Rautanen, Anna Verheij, Theo Chapman, Stephen Hinds, Charles Naranbhai, Vivek Parks, Tom Butler, Christopher Hill, Adrian Mills, Tara Elliott, Katherine Garrard, Chris
source	Medline; PMC
abstract	Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM 1,2, and 3) are viral restriction factors that mediate cellular resistance to several viruses. We have genotyped a possible splice-site altering single-nucleotide polymorphism (rs12252) in the IFITM3 gene in 34 patients with H1N1 influenza and severe pneumonia, and >5000 individuals comprising patients with community-acquired mild lower respiratory tract infection and matched controls of Caucasian ancestry. We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care) but could not confirm a previously reported association between this single-nucleotide polymorphism and susceptibility to severe H1N1 infection.
has issue date	2013-08-30(xsd:dateTime)
bibo:doi	10.1093/infdis/jit468
bibo:pmid	23997235
has license	hybrid-oa
sha1sum (hex)	6b2bd209f924e6f5aee2deff305b3a77fd322646
schema:url	https://doi.org/10.1093/infdis/jit468
resource representing a document's title	IFITM3 and Susceptibility to Respiratory Viral Infections in the Community
has PubMed Central identifier	PMC3952664
has PubMed identifier	23997235
schema:publication	Journal of Infectious Diseases
resource representing a document's body	covid:6b2bd209f924e6f5aee2deff305b3a77fd322646#body_text
is schema:about of	named entity 'primary care' named entity 'mild' named entity 'patients' named entity 'Susceptibility' named entity 'IFITM3 GENE' named entity 'SUSCEPTIBILITY' named entity 'COMMUNITY' named entity 'FOUND' named entity 'POSSIBLE' named entity 'ALLELE' named entity 'PATIENTS' named entity 'SEVERE PNEUMONIA' named entity 'INFECTION' named entity 'MATCHED' named entity 'HAVE' named entity 'ATTENDING' named entity 'PREVIOUSLY' named entity 'MEDIATE' named entity 'RESTRICTION' named entity 'INDIVIDUALS' named entity 'VIRUSES' named entity 'HOMOZYGOTES' named entity 'INTERFERON' named entity 'H1N1 INFLUENZA' named entity 'TRANSMEMBRANE PROTEINS' named entity 'CAUCASIAN' named entity 'RESPIRATORY' named entity 'VIRAL' named entity 'EVIDENCE OF' named entity 'MILD' named entity 'SEVERE' named entity 'RARE' named entity 'CONFIRM' named entity 'ACQUIRED' named entity 'PRIMARY CARE' named entity 'CELLULAR' named entity 'REPORTED' named entity 'SPLICE-SITE' named entity 'ALTERING' named entity 'SUSCEPTIBILITY' named entity 'RESISTANCE TO' named entity 'LOWER RESPIRATORY TRACT INFECTION' named entity 'ASSOCIATION' named entity 'COMMUNITY' named entity 'INFLUENZA' named entity 'BUT' named entity 'SINGLE-NUCLEOTIDE POLYMORPHISM' named entity 'INDUCIBLE' named entity 'VIRAL INFECTIONS' named entity 'H1N1' named entity 'IFITM3' covid:arg/6b2bd209f924e6f5aee2deff305b3a77fd322646 named entity 'factors' named entity 'severe' named entity 'susceptibility' named entity 'viruses' named entity 'mediate' named entity 'respiratory tract' named entity 'splice-site' named entity 'single-nucleotide polymorphism' named entity 'homozygotes' named entity 'severe pneumonia' named entity 'viruses' named entity 'influenza' named entity 'gene' named entity 'genotyped' named entity 'community-acquired' named entity 'LRTI'

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