About: Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response

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About: Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response
Creator	Li, Yan Zhou, Hong Cao, Hongwei Chen, Ming Zheng, Jiang Zhu, Yuanfeng
Source	Elsevier; Medline; PMC
abstract	A dangerous cytokine storm occurs in the SARS involving in immune disorder, but many aspects of the pathogenetic mechanism remain obscure since its outbreak. To deeply reveal the interaction of host and SARS-CoV, based on the basic structural feature of pathogen-associated molecular pattern, we created a new bioinformatics method for searching potential pathogenic molecules and identified a set of SARS-CoV specific GU-rich ssRNA fragments with a high-density distribution in the genome. In vitro experiments, the result showed the representative SARS-CoV ssRNAs had powerful immunostimulatory activities to induce considerable level of pro-inflammatory cytokine TNF-a, IL-6 and IL-12 release via the TLR7 and TLR8, almost 2-fold higher than the strong stimulatory ssRNA40 that was found previously from other virus. Moreover, SARS-CoV ssRNA was able to cause acute lung injury in mice with a high mortality rate in vivo experiment. It suggests that SARS-CoV specific GU-rich ssRNA plays a very important role in the cytokine storm associated with a dysregulation of the innate immunity. This study not only presents new evidence about the immunopathologic damage caused by overactive inflammation during the SARS-CoV infection, but also provides a useful clue for a new therapeutic strategy.
has issue date	2012-10-30(xsd:dateTime)
bibo:doi	10.1016/j.micinf.2012.10.008
bibo:pmid	23123977
has license	no-cc
sha1sum (hex)	6b3a1f73215b2c0ff5dfe585325ef8d9de79da1c
schema:url	https://doi.org/10.1016/j.micinf.2012.10.008
resource representing a document's title	Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response
has PubMed Central identifier	PMC7110875
has PubMed identifier	23123977
schema:publication	Microbes Infect
resource representing a document's body	covid:6b3a1f73215b2c0ff5dfe585325ef8d9de79da1c#body_text
is schema:about of	named entity 'ssRNA' named entity 'release' named entity 'inflammation' named entity 'ssRNA' named entity 'acute lung injury' named entity 'vivo' named entity 'specific' named entity 'SINGLE' named entity 'IDENTIFIED' named entity 'CYTOKINE ' named entity 'ALMOST' named entity 'TNF-A' named entity 'IL-6' named entity 'SSRNA' named entity 'INDUCE' named entity 'STRATEGY' named entity 'PATHOGENIC' named entity 'BIOINFORMATICS METHOD' named entity 'MOLECULES' named entity 'RESULT' named entity 'BASED' named entity 'ACTIVITIES' named entity 'VERY IMPORTANT' named entity 'HIGH-DENSITY' named entity 'INTERACTION' named entity 'IN VITRO' named entity 'BUT' named entity 'MICE' named entity 'SARS-COV' named entity 'DAMAGE' named entity 'INNATE IMMUNITY' named entity 'BASIC' named entity 'POWERFUL' named entity 'DISTRIBUTION' named entity 'MECHANISM' named entity 'PREVIOUSLY' named entity 'INFLAMMATION' named entity 'FEATURE' named entity 'FRAGMENTS' named entity 'OBSCURE' named entity 'REPRESENTATIVE' named entity 'HOST' named entity 'FOUND' named entity 'CAUSE' named entity 'POTENTIAL' named entity 'STRAND' named entity 'IDENTIFIED' named entity 'IN VIVO EXPERIMENT' named entity 'ROLE' named entity 'SARS CORONAVIRUS' named entity 'INNATE IMMUNE RESPONSE' named entity 'RICH' named entity 'EXCESSIVE' named entity 'RNA' named entity 'ACUTE LUNG INJURY' named entity 'SET' named entity 'CREATED' named entity 'FOLD' named entity 'HIGH' named entity 'ABOUT' named entity 'PATHOGEN' named entity 'EXPERIMENTS' named entity 'MOLECULAR' named entity 'GENOME' named entity 'HIGHER' named entity 'STRONG' named entity 'DEEPLY' named entity 'ASSOCIATED' named entity 'TLR7' named entity 'SPECIFIC' named entity 'ITS' named entity 'INVOLVING' named entity 'MORTALITY RATE' named entity 'RICH' named entity 'EVIDENCE' named entity 'PROVIDES'

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