About: Histiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infection

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About: Histiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Histiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infection
Creator	María, • Alonso-Riaño, Marina Antonio, Anabel Cabello, Alfonso Calpena, Silvia Carrillo, Irene Castellanos, Marina Cornejo, Ignacio Córdoba, Raúl Fortes, José Fresneda, Diana Górgolas, Miguel Lafarga, Miguel Lazaro-Garcia, Alberto Peces-Barba, Germán Petkova, Elizabet Piris, Miguel Prieto-Pérez, Laura Recuero, Sheila Rubio-Martín, Rafael Silva, Andrés Valverde-Monge, Marcela Vidal-González, Ánxela Beatriz Álvarez, • Blanco De Cordova, Astilleros Cedeño, • Cortti, José De La Fuente, Soraya Itziar Fernández-Ormaechea, • Laura, • López De Las Heras, Marta María Rodríguez-Pinilla, Socorro Medrano, José Ramón Pérez-Tanoira, • Soto, •
Source	Medline; PMC
abstract	The spectrum of COVID-19 infection includes acute respiratory distress syndrome (ARDS) and macrophage activation syndrome (MAS), although the histological basis for these disorders has not been thoroughly explored. Post-mortem pulmonary and bone marrow biopsies were performed in 33 patients. Samples were studied with a combination of morphological and immunohistochemical techniques. Bone marrow studies were also performed in three living patients. Bone marrow post-mortem studies showed striking lesions of histiocytic hyperplasia with hemophagocytosis (HHH) in most (16/17) cases. This was also observed in three alive patients, where it mimicked the changes observed in hemophagocytic histiocytosis. Pulmonary changes included a combination of diffuse alveolar damage with fibrinous microthrombi predominantly involving small vessels, in particular the alveolar capillary. These findings were associated with the analytical and clinical symptoms, which helps us understand the respiratory insufficiency and reveal the histological substrate for the macrophage activation syndrome-like exhibited by these patients. Our results confirm that COVID-19 infection triggers a systemic immune-inflammatory disease and allow specific therapies to be proposed.
has issue date	2020-07-03(xsd:dateTime)
bibo:doi	10.1038/s41379-020-0613-1
bibo:pmid	32620916
has license	no-cc
sha1sum (hex)	6b911d3a58c77793b586fa3cd7509e7a5bea6014
schema:url	https://doi.org/10.1038/s41379-020-0613-1
resource representing a document's title	Histiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infection
has PubMed Central identifier	PMC7333227
has PubMed identifier	32620916
schema:publication	Mod Pathol
resource representing a document's body	covid:6b911d3a58c77793b586fa3cd7509e7a5bea6014#body_text
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