About: The expanding roles of endoplasmic reticulum stress in virus replication and pathogenesis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The expanding roles of endoplasmic reticulum stress in virus replication and pathogenesis
Creator	Li, Shanshan Kong, Lingbao Yu, Xilan
Source	Medline; PMC
abstract	The endoplasmic reticulum (ER) is a cellular membrane organelle that plays important roles in virus replication and maturation. Accumulating evidence indicates that virus infection often disturbs ER homeostasis and leads to ER stress, which is associated with a variety of prevalent diseases. To cope with the deleterious effects of virus-induced ER stress, cells activate critical signaling pathways including the unfolded protein response (UPR) and intrinsic mitochondrial apoptosis, which have complex effects on virus replication and pathogenesis. In this review, we present a comprehensive summary of recent research in this field, which revealed that about 36 viruses trigger ER stress and differentially activate ER stress-related signaling pathways. We also highlight the strategies evolved by viruses to modulate ER stress-related signaling networks including immune responses in order to ensure their survival and pathogenesis. Together, the knowledge gained from this field will shed light on unveiling the mechanisms of virus replication and pathogenesis and provide insight for future research as well as antiviral development.
has issue date	2013-09-09(xsd:dateTime)
bibo:doi	10.3109/1040841x.2013.813899
bibo:pmid	25168431
has license	no-cc
sha1sum (hex)	6b94d37edd80f951b27c6ccf5d04ad8f46c50778
schema:url	https://doi.org/10.3109/1040841x.2013.813899
resource representing a document's title	The expanding roles of endoplasmic reticulum stress in virus replication and pathogenesis
has PubMed Central identifier	PMC7113905
has PubMed identifier	25168431
schema:publication	Crit Rev Microbiol
resource representing a document's body	covid:6b94d37edd80f951b27c6ccf5d04ad8f46c50778#body_text
is schema:about of	named entity 'DEVELOPMENT' named entity 'CELLS' named entity 'PATHOGENESIS' named entity 'MITOCHONDRIAL' named entity 'ABOUT' named entity 'VIRUS' named entity 'EFFECTS' named entity 'ASSOCIATED WITH' named entity 'VIRUS REPLICATION' named entity 'ACTIVATE' named entity 'HOMEOSTASIS' named entity 'SIGNALING NETWORKS' named entity 'REVIEW' named entity 'COMPREHENSIVE' named entity 'CELLULAR MEMBRANE' named entity 'GAINED' named entity 'APOPTOSIS' named entity 'PREVALENT' named entity 'FIELD' named entity 'ACCUMULATING' named entity 'MODULATE' named entity 'MECHANISMS' named entity 'ORGANELLE' named entity 'SUMMARY' named entity 'COMPLEX' named entity 'ER STRESS' named entity 'REVEALED' named entity 'ROLES' named entity 'ROLES' named entity 'PATHOGENESIS' named entity 'FUTURE' named entity 'RELATED' named entity 'INTRINSIC' named entity 'SIGNALING PATHWAYS' named entity 'INCLUDING' named entity 'VIRUS INFECTION' named entity 'IS A' named entity 'SURVIVAL' named entity 'IMMUNE RESPONSES' named entity 'STRATEGIES' named entity 'HAVE' named entity 'ORDER' named entity 'THEIR' named entity 'ANTIVIRAL' named entity 'KNOWLEDGE' named entity 'PROVIDE' named entity 'RECENT' named entity 'ENDOPLASMIC RETICULUM' named entity 'EVIDENCE' named entity 'IMPORTANT' named entity 'MATURATION' named entity 'COPE' named entity 'ENSURE' named entity 'RESEARCH' named entity 'EVOLVED' named entity 'INDUCED' named entity 'PLAYS' named entity 'DISEASES' named entity 'LIGHT' named entity 'EXPANDING' named entity 'UNFOLDED PROTEIN RESPONSE' named entity 'PRESENT' named entity 'VIRUS REPLICATION' named entity 'ENDOPLASMIC RETICULUM STRESS' named entity 'VARIETY' named entity 'CRITICAL' named entity 'TRIGGER' named entity 'INSIGHT' named entity 'LEADS' named entity 'VIRUSES' named entity 'virus replication' named entity 'organelle' named entity 'pathogenesis' named entity 'mRNAs' named entity 'PP1' named entity 'Salubrinal' named entity 'HCV' named entity 'phosphorylates' named entity 'mitochondrial'

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