About: Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

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About: Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
Creator	Zhou, Jie Barclay, Wendy Hu, Kai Shattock, Robin Barbosa, Christopher Blakney, Anna Bouton, Clément Brown, Jonathan Lin, Paulo Mckay, Paul Penn, Rebecca Polra, Krunal Rogers, Paul Samnuan, Karnyart Tam, Ying
Source	Medline; PMC
abstract	The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates the development of a rapidly scalable vaccine. Here, we present a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle (LNP) as a vaccine. We observe remarkably high and dose-dependent SARS-CoV-2 specific antibody titers in mouse sera, as well as robust neutralization of both a pseudo-virus and wild-type virus. Upon further characterization we find that the neutralization is proportional to the quantity of specific IgG and of higher magnitude than recovered COVID-19 patients. saRNA LNP immunizations induce a Th1-biased response in mice, and there is no antibody-dependent enhancement (ADE) observed. Finally, we observe high cellular responses, as characterized by IFN-γ production, upon re-stimulation with SARS-CoV-2 peptides. These data provide insight into the vaccine design and evaluation of immunogenicity to enable rapid translation to the clinic.
has issue date	2020-07-09(xsd:dateTime)
bibo:doi	10.1038/s41467-020-17409-9
bibo:pmid	32647131
has license	cc-by
sha1sum (hex)	6ba5a8ca3f82fcea6002932bafffe1264ca63709
schema:url	https://doi.org/10.1038/s41467-020-17409-9
resource representing a document's title	Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
has PubMed Central identifier	PMC7347890
has PubMed identifier	32647131
schema:publication	Nat Commun
resource representing a document's body	covid:6ba5a8ca3f82fcea6002932bafffe1264ca63709#body_text
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