About: Effect of cadmium on the expression levels of interleukin-1α and interleukin-10 cytokines in human lung cells

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About: Effect of cadmium on the expression levels of interleukin-1α and interleukin-10 cytokines in human lung cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effect of cadmium on the expression levels of interleukin-1α and interleukin-10 cytokines in human lung cells
Creator	Abdullah, Ahkinyala Badisa, Ramesh Badisa, Veera Latinwo, Lekan Odewumi, Caroline Sinclair, Andre
Source	PMC
abstract	Cadmium is an environmentally hazardous metal, which causes toxicity in humans. Inhalation of cigarette smoke and industrial fumes containing cadmium are sources of cadmium exposure. It is responsible for the malfunction of various organs, leading to disease particularly in the lungs, liver and kidneys. In the present study, the effect of cadmium chloride (CdCl(2)) on cell viability, and the expression levels of interleukin (IL)-1α and IL-10 cytokines at various concentrations and incubation durations were assessed in MRC-9 human normal lung and A549 human lung cancer cells to elucidate the mechanism of cadmium toxicity. Cell viability was measured using a crystal violet dye binding assay. The expression levels of the cytokines were measured by cytokine specific enzyme-linked immunosorbent assay kits. The viability assay results revealed higher sensitivity of the A549 lung cancer cells to CdCl(2) compared with the normal MRC-9 lung cells. In the normal MRC-9 lung cells, higher expression levels of the cytokines were observed at the lowest CdCl(2) concentration at a shorter exposure time compared with the lung cancer cells. Higher levels of the cytokines were observed in the A549 lung cancer cells at all other times and concentrations compared with the MRC-9 cells, indicating higher levels of inflammation. The cytokine levels were reduced at higher CdCl(2) concentrations and longer exposure durations, demonstrating the toxic effect of cadmium. The results indicated that CdCl(2) affected the expression levels of the cytokines and led to cytotoxicity in human lung cells, and suggested that compounds which reduce inflammation may prevent cadmium toxicity.
has issue date	2015-09-10(xsd:dateTime)
bibo:doi	10.3892/mmr.2015.4316
bibo:pmid	26397147
has license	cc-by-nc-nd
sha1sum (hex)	6bb0038a55ff68a2f47a36e8c845126da7fea61b
schema:url	https://doi.org/10.3892/mmr.2015.4316
resource representing a document's title	Effect of cadmium on the expression levels of interleukin-1α and interleukin-10 cytokines in human lung cells
has PubMed Central identifier	PMC4626121
has PubMed identifier	26397147
schema:publication	Mol Med Rep
resource representing a document's body	covid:6bb0038a55ff68a2f47a36e8c845126da7fea61b#body_text
is schema:about of	named entity 'EXPRESSION' named entity 'cells' named entity 'crystal violet' named entity 'NORMAL' named entity 'INTERLEUKIN-10 ' named entity 'CYTOKINE ' named entity 'CADMIUM' named entity 'ASSESSED' named entity 'CONCENTRATION' named entity 'CYTOTOXICITY' named entity 'ORGANS' named entity 'TIMES' named entity 'ENZYME-LINKED IMMUNOSORBENT ASSAY' named entity 'REDUCE' named entity 'CONCENTRATIONS' named entity 'COMPARED' named entity 'MECHANISM' named entity 'CELLS' named entity 'MEASURED' named entity 'INDICATING' named entity 'CELL VIABILITY' named entity 'INHALATION' named entity 'CADMIUM EXPOSURE' named entity 'VARIOUS' named entity 'USING' named entity 'HUMANS' named entity 'AFFECTED' named entity 'RESULTS' named entity 'SENSITIVITY' named entity 'ON CELL' named entity 'MALFUNCTION' named entity 'MRC-9' named entity 'INTERLEUKIN-1' named entity 'EFFECT' named entity 'CYTOKINES' named entity 'CELLS' named entity 'EFFECT' named entity 'METAL' named entity 'DISEASE' named entity 'HUMAN LUNG' named entity 'EXPOSURE TIME' named entity 'SOURCES' named entity 'THE LUNGS' named entity 'CIGARETTE SMOKE' named entity 'CRYSTAL VIOLET' named entity 'DURATIONS' named entity 'CYTOKINE LEVELS' named entity 'DYE' named entity 'IL-10' named entity 'INFLAMMATION' named entity 'PRESENT' named entity 'LUNG CANCER' named entity 'ASSAY' named entity 'CYTOKINES' named entity 'PREVENT' named entity 'CADMIUM TOXICITY' named entity 'BINDING ASSAY' named entity 'CADMIUM CHLORIDE' named entity 'A549' named entity 'RESPONSIBLE' named entity 'CADMIUM' named entity 'LEVELS' named entity 'TOXICITY' named entity 'HUMAN' named entity 'CAUSES' named entity 'LIVER' named entity 'SPECIFIC' named entity 'CONTAINING' named entity 'OBSERVED' named entity 'HUMAN LUNG' named entity 'INDICATED' named entity 'LEADING' named entity 'INTERLEUKIN ' named entity 'TOXIC EFFECT' named entity 'FUMES' named entity 'VIABILITY'

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