About: Relationship between post-SARS osteonecrosis and PAI-1 4G/5G gene polymorphisms

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About: Relationship between post-SARS osteonecrosis and PAI-1 4G/5G gene polymorphisms Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Relationship between post-SARS osteonecrosis and PAI-1 4G/5G gene polymorphisms
Creator	Sun, Wei Li, Zirong Wang, Bailiang Fuqiang, • Guo, Wanshou Shi, • Yang, Yurun
Source	Medline; PMC
abstract	OBJECTIVE: To explore the correlation between post-severe acute respiratory symptom (SARS) patients with osteonecrosis, investigate the etiology of post-SARS osteonecrosis and select the sensitive molecular symbols for early diagnosis and distinguish the high-risk population. METHODS: The studied subjects were divided into two groups. Sixty-two post-SARS patients with osteonecrosis were one group, and 52 age- and sex-matched healthy people were as normal controlled group. Empty stomach blood samples from cubital veins were collected from both groups. Plasminogen activator inhibitor (PAI) by means of enzyme-linked immunosorbent assay and PAI-1 4G/5G polymorphism was detected by polymerase chain reaction and solid phase oligonucleotide assay. RESULTS: The blood agents of post-SARS patients changed obviously with 15.64 ± 13.85 U/ml while the control group 7.96 ± 4.27 U/ml; 4G/4G genotype for the PAI-1 polymorphism detected in post-SARS group was more than that of the control group, but had no statistical significance. The plasma PAI activity was related to homozygote 4G/4G genotype. This reveals that homozygote 4G/4G genotype may be a susceptible gene mark to Chinese osteonecrosis patients. CONCLUSION: Plasminogen activator inhibitor-1 is sensitive blood symbol for screening high-risk susceptible population; 4G/4G PAI-1 genotype may be an etiological factor in osteonecrosis.
has issue date	2013-04-16(xsd:dateTime)
bibo:doi	10.1007/s00590-013-1223-0
bibo:pmid	23589033
has license	no-cc
sha1sum (hex)	6bc4921a6c336a939dd0313d6dc91b992bc797a7
schema:url	https://doi.org/10.1007/s00590-013-1223-0
resource representing a document's title	Relationship between post-SARS osteonecrosis and PAI-1 4G/5G gene polymorphisms
has PubMed Central identifier	PMC7087763
has PubMed identifier	23589033
schema:publication	Eur J Orthop Surg Traumatol
resource representing a document's body	covid:6bc4921a6c336a939dd0313d6dc91b992bc797a7#body_text
is schema:about of	named entity 'OSTEONECROSIS' named entity 'inhibitor' named entity 'select' named entity 'patients' named entity 'PAI-1' named entity 'SARS' named entity 'POST' named entity 'OBJECTIVE' named entity 'SELECT' named entity 'DETECTED' named entity 'METHODS' named entity 'CORRELATION' named entity 'VEINS' named entity 'NORMAL' named entity 'PEOPLE' named entity 'GROUP' named entity 'SOLID PHASE' named entity 'HIGH-RISK POPULATION' named entity 'SARS' named entity 'PAI-1' named entity 'SIXTY' named entity 'MATCHED' named entity 'POLYMERASE CHAIN REACTION' named entity 'PATIENTS' named entity 'SUBJECTS' named entity 'SEX' named entity 'SEVERE' named entity 'CUBITAL' named entity 'ENZYME-LINKED IMMUNOSORBENT ASSAY' named entity 'GROUPS' named entity 'DIVIDED' named entity 'RELATIONSHIP' named entity 'GENE POLYMORPHISMS' named entity 'POST' named entity 'RESPIRATORY SYMPTOM' named entity 'OLIGONUCLEOTIDE' named entity 'EARLY DIAGNOSIS' named entity 'ETIOLOGY' named entity 'PLASMINOGEN ACTIVATOR INHIBITOR' named entity 'PAI-1' named entity 'ACUTE' named entity 'MOLECULAR' named entity 'COLLECTED' named entity 'AGE' named entity 'POLYMORPHISM' named entity 'INVESTIGATE' named entity 'OSTEONECROSIS' named entity 'ASSAY' named entity 'MEANS' named entity 'SENSITIVE' named entity 'CONTROLLED' named entity 'HEALTHY' named entity 'BLOOD SAMPLES' named entity 'SYMBOLS' named entity 'EMPTY STOMACH' covid:arg/6bc4921a6c336a939dd0313d6dc91b992bc797a7 named entity 'respiratory' named entity 'sensitive' named entity 'explore' named entity 'symptom' named entity 'diagnosis' named entity 'healthy people' named entity 'osteonecrosis' named entity 'enzyme-linked immunosorbent assay' named entity 'stomach' named entity 'PAI-1' named entity 'SARS' named entity 'corticosteroid' named entity 'fibrinolysis' named entity 'promoter region' named entity 'anticoagulated' named entity 'PAI-1' named entity 'calibration curve' named entity 'genotypes' named entity 'supernatant'

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