About: The Effect of Mouse Hepatitis Virus Infection on the Microcirculation of the Liver

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Effect of Mouse Hepatitis Virus Infection on the Microcirculation of the Liver
Creator	Levy, Gary Macphee, Peggy Fisher, Murray Fung, Lai Rappaport, Aron
Source	PMC
abstract	Mouse hepatitis virus type 3 infection results in strain‐dependent liver disease. The effects of mouse hepatitis virus type 3 on the microcirculation of the liver in both fully susceptible (Balb/cJ) and fully resistant (A/J) mice were studied. In Balb/cJ mice, 6 to 12 hr following infection, abnormalities in liver blood flow were observed which consisted of granular blood flow in both terminal hepatic and terminal portal venules. In addition, sinusoidal microthrombi were present predominantly in periportal areas. By 24 to 48 hr, liver cell edema and small focal lesions were prominent. At 48 hr, thrombi and hepatocellular necrosis were widespread, and blood was shunted from damaged areas into patent sinusoids. In sharp contrast to these abnormal findings, normal streamlined blood flow was present in the resistant A/J animals at all time points following infection. Since large amounts of virus were demonstrated by immunofluorescene in and by recovery and growth from livers of both resistant and susceptible strains, the presence of the virus per se cannot explain the abnormalities observed.
has issue date	2007-09-21(xsd:dateTime)
bibo:doi	10.1002/hep.1840030614
bibo:pmid	6313508
has license	no-cc
sha1sum (hex)	6beff029f3c029e8c4198951616bdff8c5166264
schema:url	https://doi.org/10.1002/hep.1840030614
resource representing a document's title	The Effect of Mouse Hepatitis Virus Infection on the Microcirculation of the Liver
has PubMed Central identifier	PMC7165650
has PubMed identifier	6313508
schema:publication	Hepatology
resource representing a document's body	covid:6beff029f3c029e8c4198951616bdff8c5166264#body_text
is schema:about of	named entity 'SHUNTED' named entity 'BLOOD' named entity 'blood flow' named entity 'sinusoids' named entity 'portal venules' named entity 'microcirculation' named entity 'liver disease' named entity 'mouse hepatitis virus' named entity 'arteriole' named entity 'capillaries' named entity 'liver' named entity 'microcirculation' named entity 'histology' named entity 'abdomen' named entity 'sinusoids' named entity 'hepatocellular necrosis' named entity '1, 2' named entity 'Adams, NY' named entity 'TPV' named entity 'infection' named entity 'hepatic' named entity 'erythrocytes' named entity 'sinusoids' named entity 'hepatocytes' named entity 'white rabbits' named entity 'carbodiimide' named entity 'anesthetized' named entity 'immune response' named entity 'coronaviruses' named entity 'electron' named entity 'vascular systems' named entity 'hypersensitivity reaction' named entity 'necrotic' named entity 'liver' named entity 'microtiter plates' named entity 'reticuloendothelial' named entity 'endothelial cells' named entity 'sinusoids' named entity 'acute infection' named entity 'blood flow' named entity 'viscera' named entity 'fibrin' named entity 'cell-mediated' named entity 'viral antigens' named entity 'serine protease' named entity 'infection' named entity 'secretion' named entity '21 days' named entity 'coagulation' named entity 'microthrombi' named entity 'virus' named entity 'Tubocurarine' named entity 'monocyte' named entity 'microthrombi' named entity 'vasculitis' named entity 'granular flow' named entity 'thrombin' named entity 'mouse hepatitis virus' named entity 'virus' named entity 'body weight' named entity 'prothrombin' named entity 'endothelial cell' named entity 'hepatic' named entity 'edema' named entity 'immunofluorescence' named entity 'Lowry assay' named entity 'procoagulants' named entity 'fibrin' named entity 'hepatic' named entity 'glomerulonephritis' named entity 'liver' named entity 'skin lesions' named entity 'ductule' named entity 'edema' named entity '4.3' named entity 'parenchyma' named entity 'morphological'

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