About: Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection
Creator	Loeb, Mark Bramson, Jonathan Eskandarian, Sasha Fishman, Neil Gasink, Leanne Lemire, Mathieu Patterson, Jan Rupp, Mark Hudson, Thomas
Source	Medline; PMC
abstract	To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P = 1.88 × 10(−5); odds ratio [OR], 0.68 [95% confidence interval {CI}, .56–.81]); rs2298771 in SCN1A (sodium channel, neuronal type I α subunit) (P = 5.87 × 10(−5); OR, 1.47 [95% CI, 1.21–1.77]); and rs25651 in ANPEP (ananyl aminopeptidase) (P = 1.44 × 10(−4); OR, 0.69 [95% CI, .56–.83]). Additional genotyping of these SNPs in a separate sample of 264 case patients and 296 control patients resulted in a lack of significance in the replication cohort; joint significance was as follows: rs2066786, P = .0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease.
has issue date	2011-10-01(xsd:dateTime)
bibo:doi	10.1093/infdis/jir493
bibo:pmid	21881118
has license	bronze-oa
sha1sum (hex)	6c319149c317d6c8f08e47ff0fe2bf1af9e146bc
schema:url	https://doi.org/10.1093/infdis/jir493
resource representing a document's title	Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection
has PubMed Central identifier	PMC3203390
has PubMed identifier	21881118
schema:publication	The Journal of Infectious Diseases
resource representing a document's body	covid:6c319149c317d6c8f08e47ff0fe2bf1af9e146bc#body_text
is schema:about of	named entity 'Complications' named entity 'West Nile Virus' named entity 'Neurological Complications' named entity 'medical records' named entity 'WNV' named entity 'Canada' named entity 'linkage disequilibrium' named entity 'OAS' named entity 'identical by state' named entity 'RFC' named entity 'RFC1' named entity 'OAS' named entity 'neurological complications' named entity 'RFC' named entity 'infection' named entity 'SNPs' named entity 'case-control' named entity 'West Nile' named entity 'allele' named entity 'host factor' named entity 'viral replication' named entity 'Illumina' named entity 'Nebraska' named entity 'neuroinvasive disease' named entity 'TLR3' named entity 'SNPs' named entity 'WNV' named entity 'WNV' named entity 'institutional review board' named entity 'SNPs' named entity 'reproducibility' named entity 'WNV' named entity 'infection' named entity 'WNV' named entity 'genetic variants' named entity 'meningitis' named entity 'OAS' named entity 'genotyped' named entity 'single-nucleotide polymorphisms' named entity 'acute flaccid paralysis' named entity 'simian virus 40' named entity 'ANPEP' named entity 'SCN1A' named entity 'risk factors' named entity 'Fisher exact test' named entity 'rash' named entity 'SNPs' named entity 'monomorphic' named entity 'nonsynonymous' named entity 'WNV' named entity 'RFC' named entity 'meningitis' named entity 'CCR5' named entity 'Texas' named entity 'phenotype' named entity 'sequenced' named entity 'OAS' named entity 'inflammation' named entity 'minor allele frequency' named entity 'SNPs' named entity 'allele frequency' named entity 'Sequenom' named entity 'rare variants' named entity 'seizure disorders' named entity 'malaise' named entity 'RFC1' named entity '19, 20' named entity 'non-Hispanic white' named entity 'Sequenom' named entity 'Alberta' named entity 'amino acid sequence' named entity 'etiology' named entity 'gene'

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