About: Cell–Cell Adhesion Molecule CEACAM1 is Expressed in Normal Breast and Milk and Associates with β1 Integrin in a 3D Model of Morphogenesis

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About: Cell–Cell Adhesion Molecule CEACAM1 is Expressed in Normal Breast and Milk and Associates with β1 Integrin in a 3D Model of Morphogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cell–Cell Adhesion Molecule CEACAM1 is Expressed in Normal Breast and Milk and Associates with β1 Integrin in a 3D Model of Morphogenesis
Creator	Hardy, John Kirshner, Julia Shively, John Wilczynski, Sharon
source	PMC
abstract	CEA cell adhesion molecule-1 (CEACAM1) is a cell–cell adhesion molecule that, paradoxically, is expressed in an apical location in normal breast epithelium. Strong lumenal membrane staining is observed in 100% of normal glands (11/11), low in atypical hyperplasia (2/6), high in cribiform ductal carcinoma in situ (DCIS) (8/8), but low in other types of DCIS (2/15). Although most invasive ductal carcinomas express CEACAM1 (21/26), the staining pattern tends to be weak and cytoplasmic in tumours with minimal lumena formation (grades 2–3), while there is membrane staining in well-differentiated tumours (grade 1). The 'normal' breast epithelial line MCF10F forms acini with lumena in Matrigel with apical membrane expression of CEACAM1. MCF7 cells that do not express CEACAM1 and fail to form lumena in Matrigel, revert to a lumen forming phenotype when transfected with the CEACAM1-4S but not the -4L isoform. CEACAM1 directly associates with and down-regulates the expression of β1-integrin. Immuno-electron microscopy reveals numerous vesicles coated with CEACAM1 within the lumena, and as predicted by this finding, CEACAM1 is found in the lipid fraction of breast milk. Thus, CEACAM1 is a critical molecule in mammary morphogenesis and may play a role in the absorption of the lipid vesicles of milk in the infant intestinal tract.
has issue date	2004-01-01(xsd:dateTime)
bibo:doi	10.1023/b:hijo.0000032360.01976.81
bibo:pmid	15339048
has license	no-cc
sha1sum (hex)	6c4b47fb804c7b7ffeccd621903d2b154b63c23b
schema:url	https://doi.org/10.1023/b:hijo.0000032360.01976.81
resource representing a document's title	Cell–Cell Adhesion Molecule CEACAM1 is Expressed in Normal Breast and Milk and Associates with β1 Integrin in a 3D Model of Morphogenesis
has PubMed Central identifier	PMC7087591
has PubMed identifier	15339048
schema:publication	J Mol Histol
resource representing a document's body	covid:6c4b47fb804c7b7ffeccd621903d2b154b63c23b#body_text
is schema:about of	named entity 'NORMAL BREAST' named entity 'reveals' named entity 'vesicles' named entity 'INTEGRIN' named entity 'ASSOCIATES' named entity 'CRIBIFORM' named entity 'DO NOT' named entity 'STAINING' named entity 'B21' named entity 'DIRECTLY' named entity 'INTESTINAL TRACT' named entity 'FORMS' named entity 'MATRIGEL' named entity 'EXPRESSED' named entity 'MORPHOGENESIS' named entity 'VESICLES' named entity 'EXPRESSION' named entity 'HIGH' named entity 'FOUND' named entity '2F8' named entity 'MEMBRANE STAINING' named entity 'TYPES' named entity 'DCIS' named entity 'ABSORPTION' named entity 'LUMEN' named entity 'MCF7' named entity 'CELL ADHESION MOLECULE-1' named entity '288' named entity 'NORMAL BREAST' named entity 'DUCTAL CARCINOMA IN SITU' named entity 'PATTERN' named entity 'PHENOTYPE' named entity 'INVASIVE' named entity 'LOCATION' named entity 'CEACAM1' named entity 'BREAST' named entity 'GLANDS' named entity 'MILK' named entity 'CELLS' named entity 'REVERT' named entity 'CELL-CELL ADHESION MOLECULE' named entity 'ACINI' named entity 'REVEALS' named entity 'COATED' named entity 'STRONG' named entity 'WELL-DIFFERENTIATED' named entity 'FORMING' named entity '282' named entity 'IMMUNO-ELECTRON MICROSCOPY' named entity 'PLAY' named entity '2-3' named entity 'FINDING' named entity 'CELL-CELL ADHESION MOLECULE' named entity 'B21' named entity 'FRACTION OF' named entity 'LOW' named entity 'EXPRESS' named entity '3D MODEL' named entity 'MODEL OF' named entity 'MORPHOGENESIS' named entity 'WEAK' named entity 'CRITICAL' named entity 'APICAL' named entity 'LIPID' named entity '100%' named entity 'MAMMARY' named entity 'A CELL' named entity 'FORMATION' named entity 'INTEGRIN' named entity 'FAIL' named entity 'OBSERVED' named entity 'EPITHELIAL' named entity 'APICAL MEMBRANE' named entity 'TUMOURS' named entity 'MILK' named entity 'NUMEROUS' named entity 'EXPRESSED' named entity 'ISOFORM'

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