About: Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus

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About: Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus
Creator	Peng, Bi-Hung Algaissi, Abdullah Garron, Tania Narayanan, Krishna Tao, Xinrong Tseng, Chien-Te Couch, Robert Shankar Agrawal, Anurodh
source	Medline; PMC
abstract	To determine if a hypersensitive-type lung pathology might occur when mice were given an inactivated MERS-CoV vaccine and challenged with infectious virus as was seen with SARS-CoV vaccines, we prepared and vaccinated mice with an inactivated MERS-CoV vaccine. Neutralizing antibody was induced by vaccine with and without adjuvant and lung virus was reduced in vaccinated mice after challenge. Lung mononuclear infiltrates occurred in all groups after virus challenge but with increased infiltrates that contained eosinophils and increases in the eosinophil promoting IL-5 and IL-13 cytokines only in the vaccine groups. Inactivated MERS-CoV vaccine appears to carry a hypersensitive-type lung pathology risk from MERS-CoV infection that is similar to that found with inactivated SARS-CoV vaccines from SARS-CoV infection.
has issue date	2016-06-07(xsd:dateTime)
bibo:doi	10.1080/21645515.2016.1177688
bibo:pmid	27269431
has license	bronze-oa
sha1sum (hex)	6c88b82336b5fe551cc4ce0599825f0eca69b1d3
schema:url	https://doi.org/10.1080/21645515.2016.1177688
resource representing a document's title	Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus
has PubMed Central identifier	PMC5027702
has PubMed identifier	27269431
schema:publication	Human Vaccines & Immunotherapeutics
resource representing a document's body	covid:6c88b82336b5fe551cc4ce0599825f0eca69b1d3#body_text
is schema:about of	named entity 'induced' named entity 'vaccine' named entity 'vaccine' named entity 'MERS-CoV' named entity 'VIRUS' named entity 'IMMUNIZATION' named entity 'INACTIVATED' named entity 'IL-13' named entity 'SARS-COV INFECTION' named entity 'PREPARED' named entity 'INFECTIOUS' named entity 'VACCINATED' named entity 'CARRY' named entity 'INACTIVATED' named entity 'DETERMINE' named entity 'PATHOLOGY' named entity 'EOSINOPHILS' named entity 'SARS-COV' named entity 'INCREASES' named entity 'EOSINOPHIL' named entity 'IL-5' named entity 'PROMOTING' named entity 'MERS-COV' named entity 'VACCINE' named entity 'TYPE' named entity 'LUNG' named entity 'GROUPS' named entity 'LUNG' named entity 'CONTAINED' named entity 'INDUCED' named entity 'ADJUVANT' named entity 'MONONUCLEAR' named entity 'NEUTRALIZING ANTIBODY' named entity 'VACCINES' named entity 'HYPERSENSITIVE' named entity 'FOUND' named entity 'CHALLENGE' named entity 'IMMUNOPATHOLOGY' named entity 'LEADS' named entity 'CORONAVIRUS VACCINE' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'MICE' named entity 'SIMILAR' named entity 'CYTOKINES' named entity 'CHALLENGE' named entity 'SEEN' named entity 'REDUCED' named entity 'BUT' named entity 'INFECTION' named entity 'VIRUS' named entity 'GIVEN' named entity 'RISK' named entity 'INCREASED' named entity 'LIVE' named entity 'INFILTRATES' named entity 'OCCUR' covid:arg/6c88b82336b5fe551cc4ce0599825f0eca69b1d3 named entity 'reduced' named entity 'promoting' named entity 'SARS-CoV' named entity 'MERS-CoV' named entity 'contained' named entity 'determine' named entity 'Lung' named entity 'virus' named entity 'mice' named entity 'MERS-CoV' named entity 'cytokines' named entity 'MERS-CoV' named entity 'IL-13' named entity 'pathology' named entity 'eosinophil' named entity 'adjuvant' named entity 'Lung'

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