About: 4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound

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About: 4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound
Creator	Ward, M Gerrard, J White, J Billah, M Broekman, M Butler, A Cuatrecasas, P Feinstein, M Lapetina, E Mann, K Marcus, A Peterson, D Taylor, F Vanderhoek, J Walenga, R
source	PMC
abstract	Derivatives of flavan have been synthesized as chemical intermediates, but the only reported biological action is the ability of certain alkyl and alkoxy derivatives to lower blood cholesterol concentrations(1). It was therefore surprising to discover that flavan itself (Table 1) is a highly effective inhibitor of the replication of certain serotypes of rhinovirus, and that a simple derivative, BW683C (4′,6-dichloroflavan), is the most potent antiviral compound yet reported. The present work examines the antiviral activity of flavan derivatives with a view to selecting the compound most suitable for trial in volunteers infected with a common cold virus.
has issue date	1981-01-01(xsd:dateTime)
bibo:doi	10.1038/292369a0
bibo:pmid	6265792
has license	no-cc
sha1sum (hex)	6c95e638036cc3250cbae64343634b2d198d0955
schema:url	https://doi.org/10.1038/292369a0
resource representing a document's title	4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound
has PubMed Central identifier	PMC7094996
has PubMed identifier	6265792
schema:publication	Nature
resource representing a document's body	covid:6c95e638036cc3250cbae64343634b2d198d0955#body_text
is schema:about of	named entity 'ANTIVIRAL' named entity 'WORK' named entity 'ALKOXY' named entity 'CHEMICAL' named entity 'alkyl' named entity 'rhinovirus' named entity 'alkoxy' named entity 'antiviral activity' named entity 'rhinovirus' named entity '1 ml' named entity 'liver' named entity 'cytotoxic effects' named entity 'subcutaneous administration' named entity 'aqueous suspension' named entity 'lung' named entity 'Nature' named entity 'virus' named entity 'centrifuging' named entity 'plasma' named entity 'citric acid' named entity 'aqueous' named entity 'mass spectrometer' named entity 'uridine' named entity 'antiviral activity' named entity 'viral RNA' named entity 'tissue culture' named entity 'radioactively labelled' named entity 'ion' named entity 'LD50' named entity 'homogenate' named entity 'infectivity' named entity 'Flavan' named entity 'adenovirus' named entity 'tritiated' named entity 'rhinovirus' named entity 'virus' named entity 'virus' named entity 'virus' named entity 'growth cycle' named entity 'chromatography' named entity 'peak concentrations' named entity 'microsome' named entity 'active compound' named entity 'plasma' named entity 'substituent' named entity 'increase with time' named entity 'antiviral' named entity 'halogen' named entity 'aqueous solubility' named entity 'antiviral activity' named entity 'rhinovirus' named entity 'gas-liquid chromatography' named entity 'lung' named entity 'mutagenicity' named entity 'Ames test' named entity 'centrifuged' named entity 'logarithm' named entity 'chlorine' named entity 'poliovirus' named entity 'autoradiography' named entity 'serotypes' named entity 'Sindbis' named entity 'virus' named entity 'soluble in water' named entity 'prophylaxis' named entity 'DNA viruses' named entity 'rhinovirus'

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