About: Acute Respiratory Distress Syndrome is a TH17-like and Treg immune disease

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Acute Respiratory Distress Syndrome is a TH17-like and Treg immune disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Acute Respiratory Distress Syndrome is a TH17-like and Treg immune disease
Creator	Hu, Wan-Chung
Source	ArXiv
abstract	Acute Respiratory Distress Syndrome (ARDS) is a very severe syndrome leading to respiratory failure and subsequent mortality. Sepsis is one of the leading causes of ARDS. Thus, extracellular bacteria play an important role in the pathophysiology of ARDS. Overactivated neutrophils are the major effector cells in ARDS. Thus, extracellular bacteria triggered TH17-like innate immunity with neutrophil activation might accounts for the etiology of ARDS. Here, microarray analysis was employed to describe TH17-like innate immunity-related cytokine including TGF-{/beta} and IL-6 up-regulation in whole blood of ARDS patients. It was found that the innate TH17-related TLR1,2,4,5,8, HSP70, G-CSF, GM-CSF, complements, defensin, PMN chemokines, cathepsins, Fc receptors, NCFs, FOS, JunB, CEBPs, NFkB, and leukotriene B4 are all up-regulated. TGF-{/beta} secreting Treg cells play important roles in lung fibrosis. Up-regulation of Treg associated STAT5B and TGF-{/beta} with down-regulation of MHC genes, TCR genes, and co-stimulation molecule CD86 are noted. Key TH17 transcription factors, STAT3 and ROR{/alpha}, are down-regulated. Thus, the full adaptive TH17 helper CD4 T cells may not be successfully triggered. Many fibrosis promoting genes are also up-regulated including MMP8, MMP9, FGF13, TIMP1, TIMP2, PLOD1, P4HB, P4HA1, PDGFC, HMMR, HS2ST1, CHSY1, and CSGALNACT. Failure to induce successful adaptive immunity could also attribute to ARDS pathogenesis. Thus, ARDS is actually a TH17-like and Treg immune disorder.
has issue date	2013-11-18(xsd:dateTime)
has license	arxiv
sha1sum (hex)	6cb78069db9c79322b2469ca340468d6e8b62038
resource representing a document's title	Acute Respiratory Distress Syndrome is a TH17-like and Treg immune disease
resource representing a document's body	covid:6cb78069db9c79322b2469ca340468d6e8b62038#body_text
is schema:about of	named entity 'ARDS' named entity 'neutrophils' named entity 'MICROARRAY ANALYSIS' named entity 'RELATED' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'ETIOLOGY' named entity 'CELLS' named entity 'ONE OF' named entity 'NEUTROPHILS' named entity 'BACTERIA ' named entity 'INCLUDING' named entity 'TGF-β' named entity 'hemorrhagic shock' named entity 'KLRD1' named entity 'TLR8' named entity 'down-regulated' named entity 'TH17' named entity 'ARDS' named entity 'pulmonary surfactants' named entity 'ARDS' named entity 'Qiagen' named entity 'Treg' named entity 'ARDS' named entity 'receptor' named entity 'abscess' named entity 'etiology' named entity 'CD8 T cells' named entity 'infection' named entity 'alveolar spaces' named entity 'ARDS' named entity 'IL-1' named entity 'TH17' named entity 'heat shock protein' named entity 'effector cells' named entity 'ARDS' named entity 'neutrophil' named entity 'internal control' named entity 'up-regulated' named entity 'Treg cells' named entity 'sepsis' named entity 'antigen' named entity 'eosinophil' named entity 'TH1' named entity '49, 50' named entity 'C5AR1' named entity 'complement' named entity 'STAT1' named entity 'innate immunity' named entity 'STAT5B' named entity 'extracellular' named entity 'leukotriene B4' named entity 'Plasmodium falciparum' named entity 'bacteria' named entity 'upregulated' named entity 'Gene Expression' named entity 'ARDS' named entity 'up-regulation' named entity 'Microarray analysis' named entity 'sepsis' named entity 'neutrophils' named entity 'bacteria' named entity 'TLR1' named entity 'TH17' named entity 'extracellular' named entity 'CSF3' named entity 'transcription factor' named entity 'IL32' named entity 'CD molecules' named entity 'ARDS' named entity 'transcription factors' named entity 'boxplot' named entity 'RHAMM' named entity 'MHC' named entity 'down-regulated' named entity 'HSPA1B' named entity 'RNA' named entity 'bacteremia' named entity 'TNFRSF1A' named entity 'dioxygenase' named entity 'ARDS' named entity 'lung injury' named entity 'up-regulated' named entity 'IL1A' named entity 'antibody' named entity 'epithelial cells' named entity 'STAT3' named entity 'human genes'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software