About: Analysis on the Pathogenesis of Symptomatic Pulmonary Embolism with Human Genomics

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Analysis on the Pathogenesis of Symptomatic Pulmonary Embolism with Human Genomics
Creator	Wang, Qiang Yang, Fan Wang, Hao Duan, Qianglin Wang, Lemin Gong, Zhu Song, Haoming Song, Yanli Liang, Aibin
Source	PMC
abstract	BACKGROUND: In the present study, the whole human genome oligo microarray was employed to investigate the gene expression profile in symptomatic pulmonary embolism (PE). METHODS: Twenty patients with PE and 20 age and gender matched patients without PE as controls were enrolled into the present study in the same period. The diagnosis of PE was based on the clinical manifestations and findings on imaging examinations. Acute arterial and/or venous thrombosis was excluded in controls. The whole human genome oligo microarray was employed for detection. Statistical analysis was performed with t test following analysis of very small samples of repeated measurements and Gene Ontology (GO) analysis. RESULTS: Genomic data showed no damage to vascular endothelial cells in PE patients. Genomic data only found increased mRNA expression of a small amount of coagulation factors in PE patients. In the PE group, anticoagulant proteins, Fibrinolytic system and proteins related to platelet functions only played partial roles in the pathogenesis of PE. In addition, the mRNA expressions of a fraction of adhesion molecules were markedly up-regulated. Gene Ontology analysis showed the genes with down-regulated expressions mainly explain the compromised T cell immunity. Symptomatic VTE patients have compromised T cell immunity. CONCLUSION: The damage to vascular endothelial cells is not necessary in the pathogenesis of VTE, and only a fraction of factors involved in the shared coagulation cascade are activated. Genomic results may provide a new clue for clinical diagnosis, treatment and prevention of VTE.
has issue date	2012-07-11(xsd:dateTime)
bibo:doi	10.7150/ijms.4641
bibo:pmid	22811612
has license	cc-by-nc-nd
sha1sum (hex)	6ce22e4f892e54b0f6317315b113f3fd46ed7245
schema:url	https://doi.org/10.7150/ijms.4641
resource representing a document's title	Analysis on the Pathogenesis of Symptomatic Pulmonary Embolism with Human Genomics
has PubMed Central identifier	PMC3399218
has PubMed identifier	22811612
schema:publication	Int J Med Sci
resource representing a document's body	covid:6ce22e4f892e54b0f6317315b113f3fd46ed7245#body_text
is schema:about of	named entity 'AGE' named entity 'NEW' named entity 'T TEST' named entity 'INCREASED' named entity 'DOWN-REGULATED' named entity 'BASED' named entity 'FRACTION OF' named entity 'COAGULATION' named entity 'FOLLOWING' named entity 'PATHOGENESIS' named entity 'ACTIVATED' named entity 'PULMONARY EMBOLISM' named entity 'VTE' named entity 'PERFORMED' named entity 'PARTIAL' named entity 'ENDOTHELIAL CELLS' named entity 'ACUTE' named entity 'RELATED' named entity 'coagulation factors' named entity 'vascular' named entity 'study' named entity 'damage' named entity 'human genome' named entity 'shared' named entity 'proteins' named entity 'patients' named entity 'T CELL IMMUNITY' named entity 'HAVE' named entity 'GENOMIC DATA' named entity 'ROLES' named entity 'EXPRESSIONS' named entity 'SHARED' named entity 'SYMPTOMATIC' named entity 'GENE EXPRESSION PROFILE' named entity 'FUNCTIONS' named entity 'EMPLOYED' named entity 'RESULTS' named entity 'GENOMIC' named entity 'PATHOGENESIS' named entity 'PULMONARY EMBOLISM' named entity 'HUMAN GENOMICS' named entity 'VERY SMALL' named entity 'VENOUS THROMBOSIS' named entity 'TWENTY' named entity 'PRESENT' named entity 'MATCHED' named entity 'CLINICAL MANIFESTATIONS' named entity 'MRNA EXPRESSION' named entity 'ENROLLED' named entity 'ANALYSIS' named entity 'PLAYED' named entity 'TO INVESTIGATE' named entity 'GENE ONTOLOGY' named entity 'GENES' named entity 'EXAMINATIONS' named entity 'PLATELET' named entity 'COAGULATION FACTORS' named entity 'PREVENTION OF' named entity 'PATIENTS' named entity 'ADHESION MOLECULES' named entity 'CONCLUSION' named entity 'TREATMENT' named entity 'ANALYSIS' named entity 'STUDY' named entity 'MRNA' named entity 'MARKEDLY' named entity 'INVOLVED' named entity 'NECESSARY' named entity 'GENDER' named entity 'IMAGING' named entity 'DETECTION' named entity 'SAMPLES' named entity 'ADDITION'

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